SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK)
1_MDAAL 6_ KRSRS 11_ EEPAE 16_ ILPPA 21_ RDEEE 26_ EEEEG 31_ MEQGL 36_ EEEEE 41_ VDPRI 46_ QGELE 51_ KLNQS 56_ TDDIN 61_ RRETE 66_ LEDAR 71_ QKFRS 76_ VLVEA 81_ TVKLD 86_ ELVKK 91_ IGKAV 96_ EDSKP 101_ YWEAR 106_ RVARQ 111_ AQLEA 116_ QKATQ 121_ DFQRA 126_ TEVLR 131_ AAKET 136_ ISLAE 141_ QRLLE 146_ DDKRQ 151_ FDSAW 156_ QEMLN 161_ HATQR 166_ VMEAE 171_ QTKTR 176_ SELVH 181_ KETAA 186_ RYNAA 191_ MGRMR 196_ QLEKK 201_ LKRAI 206_ NKSKP 211_ YFELK 216_ AKYYV 221_ QLEQL 226_ KKTVD 231_ DLQAK 236_ LTLAK 241_ GEYKM 246_ ALKNL 251_ EMISD 256_ EIHER 261_ RRSSA 266_ MGPRG 271_ CGVGA 276_ EGSST 281_ SVEDL 286_ PGSKP 291_ EPDAI 296_ SVASE 301_ AFEDD 306_ SCSNF 311_ VSEDD 316_ SETQS 321_ VSSFS 326_ SGPTS 331_ PSEMP 336_ DQFPA 341_ VVRPG 346_ SLDLP 351_ SPVSL 356_ SEFGM 361_ MFPVL 366_ GPRSE 371_ CSGAS 376_ SPECE 381_ VERGD 386_ RAEGA 391_ ENKTS 396_ DKANN 401_ NRGLS 406_ SSSGS 411_ GGSSK 416_ SQSST 421_ SPEGQ 426_ ALENR 431_ MKQLS 436_ LQCSK 441_ GRDGI 446_IADIK
1: Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death