Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST-1) (EC 2.8.2.-)
1_MRRRR 6_ AGGRT 11_ MVERA 16_ SKFVL 21_ VVAGS 26_ VCFML 31_ ILYQY 36_ AGPGL 41_ SLGAP 46_ GGRAP 51_ PDDLD 56_ LFPTP 61_ DPHYE 66_ KKYYF 71_ PVREL 76_ ERSLR 81_ FDMKG 86_ DDVIV 91_ FLHIQ 96_ KTGGT 101_ TFGRH 106_ LVQNV 111_ RLEVP 116_ CDCRP 121_ GQKKC 126_ TCYRP 131_ NRRET 136_ WLFSR 141_ FSTGW 146_ SCGLH 151_ ADWTE 156_ LTNCV 161_ PGVLD 166_ RRDSA 171_ ALRTP 176_ RKFYY 181_ ITLLR 186_ DPVSR 191_ YLSEW 196_ RHVQR 201_ GATWK 206_ TSLHM 211_ CDGRT 216_ PTPEE 221_ LPPCY 226_ EGTDW 231_ SGCTL 236_ QEFMD 241_ CPYNL 246_ ANNRQ 251_ VRMLA 256_ DLSLV 261_ GCYNL 266_ SFIPE 271_ GKRAQ 276_ LLLES 281_ AKKNL 286_ RGMAF 291_ FGLTE 296_ FQRKT 301_ QYLFE 306_ RTFNL 311_ KFIRP 316_ FMQYN 321_ STRAG 326_ GVEVD 331_ EDTIR 336_ RIEEL 341_ NDLDM 346_ QLYDY 351_ AKDLF 356_ QQRYQ 361_ YKRQL 366_ ERREQ 371_ RLRSR 376_ EERLL 381_ HRAKE 386_ ALPRE 391_ DADEP 396_ GRVPT 401_ EDYMS 406_HIIEK
1: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid