Protein SOX-15 (Protein SOX-12) (Protein SOX-20)
1_MALPG 6_ SSQDQ 11_ AWSLE 16_ PPAAT 21_ AAASS 26_ SSGPQ 31_ EREGA 36_ GSPAA 41_ PGTLP 46_ LEKVK 51_ RPMNA 56_ FMVWS 61_ SAQRR 66_ QMAQQ 71_ NPKMH 76_ NSEIS 81_ KRLGA 86_ QWKLL 91_ DEDEK 96_ RPFVE 101_ EAKRL 106_ RARHL 111_ RDYPD 116_ YKYRP 121_ RRKAK 126_ SSGAG 131_ PSRCG 136_ QGRGN 141_ LASGG 146_ PLWGP 151_ GYATT 156_ QPSRG 161_ FGYRP 166_ PSYST 171_ AYLPG 176_ SYGSS 181_ HCKLE 186_ APSPC 191_ SLPQS 196_ DPRLQ 201_ GELLP 206_ TYTHY 211_ LPPGS 216_ PTPYN 221_ PPLAG 226_APMPL
1: Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity). Regulates transcription of HRC via binding to it proximal enhancer region (By similarity). Involved in skeletal muscle regeneration (By similarity). Also plays a role in the development of myogenic precursor cells (By similarity)