Kallikrein-8 (hK8) (EC 3.4.21.118) (Neuropsin) (NP) (Ovasin) (Serine protease 19) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein)
1_MGRPR 6_ PRAAK 11_ TWMFL 16_ LLLGG 21_ AWAGH 26_ SRAQE 31_ DKVLG 36_ GHECQ 41_ PHSQP 46_ WQAAL 51_ FQGQQ 56_ LLCGG 61_ VLVGG 66_ NWVLT 71_ AAHCK 76_ KPKYT 81_ VRLGD 86_ HSLQN 91_ KDGPE 96_ QEIPV 101_ VQSIP 106_ HPCYN 111_ SSDVE 116_ DHNHD 121_ LMLLQ 126_ LRDQA 131_ SLGSK 136_ VKPIS 141_ LADHC 146_ TQPGQ 151_ KCTVS 156_ GWGTV 161_ TSPRE 166_ NFPDT 171_ LNCAE 176_ VKIFP 181_ QKKCE 186_ DAYPG 191_ QITDG 196_ MVCAG 201_ SSKGA 206_ DTCQG 211_ DSGGP 216_ LVCDG 221_ ALQGI 226_ TSWGS 231_ DPCGR 236_ SDKPG 241_ VYTNI 246_ CRYLD 251_WIKKI
1: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury