SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)
1_MSSAA 6_ EPPPP 11_ PPPES 16_ APSKP 21_ AASIA 26_ SGGSN 31_ SSNKG 36_ GPEGV 41_ AAQAV 46_ ASAAS 51_ AGPAD 56_ AEMEE 61_ IFDDA 66_ SPGKQ 71_ KEIQE 76_ PDPTY 81_ EEKMQ 86_ TDRAN 91_ RFEYL 96_ LKQTE 101_ LFAHF 106_ IQPAA 111_ QKTPT 116_ SPLKM 121_ KPGRP 126_ RIKKD 131_ EKQNL 136_ LSVGD 141_ YRHRR 146_ TEQEE 151_ DEELL 156_ TESSK 161_ ATNVC 166_ TRFED 171_ SPSYV 176_ KWGKL 181_ RDYQV 186_ RGLNW 191_ LISLY 196_ ENGIN 201_ GILAD 206_ EMGLG 211_ KTLQT 216_ ISLLG 221_ YMKHY 226_ RNIPG 231_ PHMVL 236_ VPKST 241_ LHNWM 246_ SEFKR 251_ WVPTL 256_ RSVCL 261_ IGDKE 266_ QRAAF 271_ VRDVL 276_ LPGEW 281_ DVCVT 286_ SYEML 291_ IKEKS 296_ VFKKF 301_ NWRYL 306_ VIDEA 311_ HRIKN 316_ EKSKL 321_ SEIVR 326_ EFKTT 331_ NRLLL 336_ TGTPL 341_ QNNLH 346_ ELWSL 351_ LNFLL 356_ PDVFN 361_ SADDF 366_ DSWFD 371_ TNNCL 376_ GDQKL 381_ VERLH 386_ MVLRP 391_ FLLRR 396_ IKADV 401_ EKSLP 406_ PKKEV 411_ KIYVG 416_ LSKMQ 421_ REWYT 426_ RILMK 431_ DIDIL 436_ NSAGK 441_ MDKMR 446_ LLNIL 451_ MQLRK 456_ CCNHP 461_ YLFDG 466_ AEPGP 471_ PYTTD 476_ MHLVT 481_ NSGKM 486_ VVLDK 491_ LLPKL 496_ KEQGS 501_ RVLIF 506_ SQMTR 511_ VLDIL 516_ EDYCM 521_ WRNYE 526_ YCRLD 531_ GQTPH 536_ DERQD 541_ SINAY 546_ NEPNS 551_ TKFVF 556_ MLSTR 561_ AGGLG 566_ INLAT 571_ ADVVI 576_ LYDSD 581_ WNPQV 586_ DLQAM 591_ DRAHR 596_ IGQTK 601_ TVRVF 606_ RFITD 611_ NTVEE 616_ RIVER 621_ AEMKL 626_ RLDSI 631_ VIQQG 636_ RLVDQ 641_ NLNKI 646_ GKDEM 651_ LQMIR 656_ HGATH 661_ VFASK 666_ ESEIT 671_ DEDID 676_ GILER 681_ GAKKT 686_ AEMNE 691_ KLSKM 696_ GESSL 701_ RNFTM 706_ DTESS 711_ VYNFE 716_ GEDYR 721_ EKQKI 726_ AFTEW 731_ IEPPK 736_ RERKA 741_ NYAVD 746_ AYFRE 751_ ALRVS 756_ EPKAP 761_ KAPRP 766_ PKQPN 771_ VQDFQ 776_ FFPPR 781_ LFELL 786_ EKEIL 791_ FYRKT 796_ IGYKV 801_ PRNPE 806_ LPNAA 811_ QAQKE 816_ EQLKI 821_ DEAES 826_ LNDEE 831_ LEEKE 836_ KLLTQ 841_ GFTNW 846_ NKRDF 851_ NQFIK 856_ ANEKW 861_ GRDDI 866_ ENIAR 871_ EVEGK 876_ TPEEV 881_ IEYSA 886_ VFWER 891_ CNELQ 896_ DIEKI 901_ MAQIE 906_ RGEAR 911_ IQRRI 916_ SIKKA 921_ LDTKI 926_ GRYKA 931_ PFHQL 936_ RISYG 941_ TNKGK 946_ NYTEE 951_ EDRFL 956_ ICMLH 961_ KLGFD 966_ KENVY 971_ DELRQ 976_ CIRNS 981_ PQFRF 986_ DWFLK 991_ SRTAM 996_ ELQRR 1001_ CNTLI 1006_ TLIER 1011_ ENMEL 1016_ EEKEK 1021_ AEKKK 1026_ RGPKP 1031_ STQKR 1036_ KMDGA 1041_ PDGRG 1046_RKKKL
1: ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity)