NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)
1_MEGAA 6_ APVAG 11_ DRPDL 16_ GLGAP 21_ GSPRE 26_ AVAGA 31_ TAALE 36_ PRKPH 41_ GVKRH 46_ HHKHN 51_ LKHRY 56_ ELQET 61_ LGKGT 66_ YGKVK 71_ RATER 76_ FSGRV 81_ VAIKS 86_ IRKDK 91_ IKDEQ 96_ DMVHI 101_ RREIE 106_ IMSSL 111_ NHPHI 116_ ISIYE 121_ VFENK 126_ DKIVI 131_ IMEYA 136_ SKGEL 141_ YDYIS 146_ ERRRL 151_ SERET 156_ RHFFR 161_ QIVSA 166_ VHYCH 171_ KNGVV 176_ HRDLK 181_ LENIL 186_ LDDNC 191_ NIKIA 196_ DFGLS 201_ NLYQK 206_ DKFLQ 211_ TFCGS 216_ PLYAS 221_ PEIVN 226_ GRPYR 231_ GPEVD 236_ SWALG 241_ VLLYT 246_ LVYGT 251_ MPFDG 256_ FDHKN 261_ LIRQI 266_ SSGEY 271_ REPTQ 276_ PSDAR 281_ GLIRW 286_ MLMVN 291_ PDRRA 296_ TIEDI 301_ ANHWW 306_ VNWGY 311_ KSSVC 316_ DCDAL 321_ HDSES 326_ PLLAR 331_ IIDWH 336_ HRSTG 341_ LQADT 346_ EAKMK 351_ GLAKP 356_ TTSEV 361_ MLERQ 366_ RSLKK 371_ SKKEN 376_ DFAQS 381_ GQDAV 386_ PESPS 391_ KLSSK 396_ RPKGI 401_ LKKRS 406_ NSEHR 411_ SHSTG 416_ FIEGV 421_ VGPAL 426_ PSTFK 431_ MEQDL 436_ CRTGV 441_ LLPSS 446_ PEAEV 451_ PGKLS 456_ PKQSA 461_ TMPKK 466_ GILKK 471_ TQQRE 476_ SGYYS 481_ SPERS 486_ ESSEL 491_ LDSND 496_ VMGSS 501_ IPSPS 506_ PPDPA 511_ RVTSH 516_ SLSCR 521_ RKGIL 526_ KHSSK 531_ YSAGT 536_ MDPAL 541_ VSPEM 546_ PTLES 551_ LSEPG 556_ VPAEG 561_ LSRSY 566_ SRPSS 571_ VISDD 576_ SVLSS 581_ DSFDL 586_ LDLQE 591_ NRPAR 596_ QRIRS 601_ CVSAE 606_ NFLQI 611_ QDFEG 616_ LQNRP 621_ RPQYL 626_ KRYRN 631_ RLADS 636_ SFSLL 641_ TDMDD 646_ VTQVY 651_ KQALE 656_ICSKL
1: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316)