E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1)
1_MGSIL 6_ SRRIA 11_ GVEDI 16_ DIQAN 21_ SAYRY 26_ PPKSG 31_ NYFAS 36_ HFFMG 41_ GEKFD 46_ TPHPE 51_ GYLFG 56_ ENMDL 61_ NFLGS 66_ RPVQF 71_ PYVTP 76_ APHEP 81_ VKTLR 86_ SLVNI 91_ RKDSL 96_ RLVRY 101_ KDDAD 106_ SPTED 111_ GDKPR 116_ VLYSL 121_ EFTFD 126_ ADARV 131_ AITIY 136_ CQASE 141_ EFLNG 146_ RAVYS 151_ PKSPS 156_ LQSET 161_ VHYKR 166_ GVSQQ 171_ FSLPS 176_ FKIDF 181_ SEWKD 186_ DELNF 191_ DLDRG 196_ VFPVV 201_ IQAVV 206_ DEGDV 211_ VEVTG 216_ HAHVL 221_ LAAFE 226_ KHMDG 231_ SFSVK 236_ PLKQK 241_ QIVDR 246_ VSYLL 251_ QEIYG 256_ IENKN 261_ NQETK 266_ PSDDE 271_ NSDNS 276_ NECVV 281_ CLSDL 286_ RDTLI 291_ LPCRH 296_ LCLCT 301_ SCADT 306_ LRYQA 311_ NNCPI 316_ CRLPF 321_ RALLQ 326_ IRAVR 331_ KKPGA 336_ LSPVS 341_ FSPVL 346_ AQSLE 351_ HDEHS 356_ CPFKK 361_ SKPHP 366_ ASLAS 371_ KKPKR 376_ ETNSD 381_ SVPPG 386_ YEPIS 391_ LLEAL 396_ NGLRA 401_ VSPAI 406_ PSAPL 411_ YEEIT 416_ YSGIS 421_ DGLSQ 426_ ASCPL 431_ AAIDH 436_ ILDSS 441_ RQKGR 446_ PQSKA 451_ PDSTL 456_ RSPSS 461_ PIHEE 466_ DEEKL 471_ SEDVD 476_ APPPL 481_ GGAEL 486_ ALRES 491_ SSPES 496_ FITEE 501_ VDESS 506_ SPQQG 511_ TRAAS 516_ IENVL 521_ QDSSP 526_ EHCGR 531_ GPPAD 536_ IYLPA 541_ LGPDS 546_CSVGI
1: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity)