RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160)
1_MAAPA 6_ QPKKI 11_ VAPTV 16_ SQINA 21_ EFVTQ 26_ LACKY 31_ WAPHI 36_ KKKSP 41_ FDIKV 46_ IEDIY 51_ EKEIV 56_ KSRFA 61_ IRKIM 66_ LLEFS 71_ QYLEN 76_ YLWMN 81_ YSPEV 86_ SSKAY 91_ LMSIC 96_ CMVNE 101_ KFREN 106_ VPAWE 111_ IFKKK 116_ PDHFP 121_ FFFKH 126_ ILKAA 131_ LAETD 136_ GEFSL 141_ HEQTV 146_ LLLFL 151_ DHCFN 156_ SLEVD 161_ LIRSQ 166_ VQQLI 171_ SLPMW 176_ MGLQL 181_ ARLEL 186_ ELKKT 191_ PKLRK 196_ FWNLI 201_ KKNDE 206_ KMDPE 211_ AREQA 216_ YQERR 221_ FLSQL 226_ IQKFI 231_ SVLKS 236_ VPLSE 241_ PVTMD 246_ KVHYC 251_ ERFIE 256_ LMIDL 261_ EALLP 266_ TRRWF 271_ NTILD 276_ DSHLL 281_ VHCYL 286_ SNLVR 291_ REEDG 296_ HLFSQ 301_ LLDML 306_ KFYTG 311_ FEIND 316_ QTGNA 321_ LTENE 326_ MTTIH 331_ YDRIT 336_ SLQRA 341_ AFAHF 346_ PELYD 351_ FALSN 356_ VAEVD 361_ TRESL 366_ VKFFG 371_ PLSSN 376_ TLHQV 381_ ASYLC 386_ LLPTL 391_ PKNED 396_ TTFDK 401_ EFLLE 406_ LLVSR 411_ HERRI 416_ SQIQQ 421_ LNQMP 426_ LYPTE 431_ KIIWD 436_ ENIVP 441_ TEYYS 446_ GEGCL 451_ ALPKL 456_ NLQFL 461_ TLHDY 466_ LLRNF 471_ NLFRL 476_ ESTYE 481_ IRQDI 486_ EDSVS 491_ RMKPW 496_ QSEYG 501_ GVVFG 506_ GWARM 511_ AQPIV 516_ AFTVV 521_ EVAKP 526_ NIGEN 531_ WPTRV 536_ RADVT 541_ INLNV 546_ RDHIK 551_ DEWEG 556_ LRKHD 561_ VCFLI 566_ TVRPT 571_ KPYGT 576_ KFDRR 581_ RPFIE 586_ QVGLV 591_ YVRGC 596_ EIQGM 601_ LDDKG 606_ RVIED 611_ GPEPR 616_ PNLRG 621_ ESRTF 626_ RVFLD 631_ PNQYQ 636_ QDMTN 641_ TIQNG 646_ AEDVY 651_ ETFNI 656_ IMRRK 661_ PKENN 666_ FKAVL 671_ ETIRN 676_ LMNTD 681_ CVVPD 686_ WLHDI 691_ ILGYG 696_ DPSSA 701_ HYSKM 706_ PNQIA 711_ TLDFN 716_ DTFLS 721_ IEHLK 726_ ASFPG 731_ HNVKV 736_ TVEDP 741_ ALQIP 746_ PFRIT 751_ FPVRS 756_ GKGKK 761_ RKDAD 766_ VEDED 771_ TEEAK 776_ TLIVE 781_ PHVIP 786_ NRGPY 791_ PYNQP 796_ KRNTI 801_ QFTHT 806_ QIEAI 811_ RAGMQ 816_ PGLTM 821_ VVGPP 826_ GTGKT 831_ DVAVQ 836_ IISNI 841_ YHNFP 846_ EQRTL 851_ IVTHS 856_ NQALN 861_ QLFEK 866_ IMALD 871_ IDERH 876_ LLRLG 881_ HGEEE 886_ LETEK 891_ DFSRY 896_ GRVNY 901_ VLARR 906_ IELLE 911_ EVKRL 916_ QKSLG 921_ VPGDA 926_ SYTCE 931_ TAGYF 936_ FLYQV 941_ MSRWE 946_ EYISK 951_ VKNKG 956_ STLPD 961_ VTEVS 966_ TFFPF 971_ HEYFA 976_ NAPQP 981_ IFKGR 986_ SYEED 991_ MEIAE 996_ GCFRH 1001_ IKKIF 1006_ TQLEE 1011_ FRASE 1016_ LLRSG 1021_ LDRSK 1026_ YLLVK 1031_ EAKII 1036_ AMTCT 1041_ HAALK 1046_ RHDLV 1051_ KLGFK 1056_ YDNIL 1061_ MEEAA 1066_ QILEI 1071_ ETFIP 1076_ LLLQN 1081_ PQDGF 1086_ SRLKR 1091_ WIMIG 1096_ DHHQL 1101_ PPVIK 1106_ NMAFQ 1111_ KYSNM 1116_ EQSLF 1121_ TRFVR 1126_ VGVPT 1131_ VDLDA 1136_ QGRAR 1141_ ASLCN 1146_ LYNWR 1151_ YKNLG 1156_ NLPHV 1161_ QLLPE 1166_ FSTAN 1171_ AGLLY 1176_ DFQLI 1181_ NVEDF 1186_ QGVGE 1191_ SEPNP 1196_ YFYQN 1201_ LGEAE 1206_ YVVAL 1211_ FMYMC 1216_ LLGYP 1221_ ADKIS 1226_ ILTTY 1231_ NGQKH 1236_ LIRDI 1241_ INRRC 1246_ GNNPL 1251_ IGRPN 1256_ KVTTV 1261_ DRFQG 1266_ QQNDY 1271_ ILLSL 1276_ VRTRA 1281_ VGHLR 1286_ DVRRL 1291_ VVAMS 1296_ RARLG 1301_ LYIFA 1306_ RVSLF 1311_ QNCFE 1316_ LTPAF 1321_ SQLTA 1326_ RPLHL 1331_ HIIPT 1336_ EPFPT 1341_ TRKNG 1346_ ERPSH 1351_ EVQII 1356_ KNMPQ 1361_ MANFV 1366_ YNMYM 1371_ HLIQT 1376_ THHYH 1381_ QTLLQ 1386_ LPPAM 1391_ VEEGE 1396_ EVQNQ 1401_ ETELE 1406_ TEEEA 1411_ MTVQA 1416_ DIIPS 1421_ PTDTS 1426_ CRQET 1431_ PAFQT 1436_ DTTPS 1441_ ETGAT 1446_ STPEA 1451_ IPALS 1456_ ETTPT 1461_ VVGAV 1466_ SAPAE 1471_ ANTPQ 1476_DATSA
1: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28076346, PubMed:28502770). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396)