Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)
1_MLSGK 6_ KAAAA 11_ AAAAA 16_ AAATG 21_ TEAGP 26_ GTAGG 31_ SENGS 36_ EVAAQ 41_ PAGLS 46_ GPAEV 51_ GPGAV 56_ GERTP 61_ RKKEP 66_ PRASP 71_ PGGLA 76_ EPPGS 81_ AGPQA 86_ GPTVV 91_ PGSAT 96_ PMETG 101_ IAETP 106_ EGRRT 111_ SRRKR 116_ AKVEY 121_ REMDE 126_ SLANL 131_ SEDEY 136_ YSEEE 141_ RNAKA 146_ EKEKK 151_ LPPPP 156_ PQAPP 161_ EEENE 166_ SEPEE 171_ PSGVE 176_ GAAFQ 181_ SRLPH 186_ DRMTS 191_ QEAAC 196_ FPDII 201_ SGPQQ 206_ TQKVF 211_ LFIRN 216_ RTLQL 221_ WLDNP 226_ KIQLT 231_ FEATL 236_ QQLEA 241_ PYNSD 246_ TVLVH 251_ RVHSY 256_ LERHG 261_ LINFG 266_ IYKRI 271_ KPLPT 276_ KKTGK 281_ VIIIG 286_ SGVSG 291_ LAAAR 296_ QLQSF 301_ GMDVT 306_ LLEAR 311_ DRVGG 316_ RVATF 321_ RKGNY 326_ VADLG 331_ AMVVT 336_ GLGGN 341_ PMAVV 346_ SKQVN 351_ MELAK 356_ IKQKC 361_ PLYEA 366_ NGQAV 371_ PKEKD 376_ EMVEQ 381_ EFNRL 386_ LEATS 391_ YLSHQ 396_ LDFNV 401_ LNNKP 406_ VSLGQ 411_ ALEVV 416_ IQLQE 421_ KHVKD 426_ EQIEH 431_ WKKIV 436_ KTQEE 441_ LKELL 446_ NKMVN 451_ LKEKI 456_ KELHQ 461_ QYKEA 466_ SEVKP 471_ PRDIT 476_ AEFLV 481_ KSKHR 486_ DLTAL 491_ CKEYD 496_ ELAET 501_ QGKLE 506_ EKLQE 511_ LEANP 516_ PSDVY 521_ LSSRD 526_ RQILD 531_ WHFAN 536_ LEFAN 541_ ATPLS 546_ TLSLK 551_ HWDQD 556_ DDFEF 561_ TGSHL 566_ TVRNG 571_ YSCVP 576_ VALAE 581_ GLDIK 586_ LNTAV 591_ RQVRY 596_ TASGC 601_ EVIAV 606_ NTRST 611_ SQTFI 616_ YKCDA 621_ VLCTL 626_ PLGVL 631_ KQQPP 636_ AVQFV 641_ PPLPE 646_ WKTSA 651_ VQRMG 656_ FGNLN 661_ KVVLC 666_ FDRVF 671_ WDPSV 676_ NLFGH 681_ VGSTT 686_ ASRGE 691_ LFLFW 696_ NLYKA 701_ PILLA 706_ LVAGE 711_ AAGIM 716_ ENISD 721_ DVIVG 726_ RCLAI 731_ LKGIF 736_ GSSAV 741_ PQPKE 746_ TVVSR 751_ WRADP 756_ WARGS 761_ YSYVA 766_ AGSSG 771_ NDYDL 776_ MAQPI 781_ TPGPS 786_ IPGAP 791_ QPIPR 796_ LFFAG 801_ EHTIR 806_ NYPAT 811_ VHGAL 816_ LSGLR 821_ EAGRI 826_ ADQFL 831_ GAMYT 836_ LPRQA 841_ TPGVP 846_AQQSP
1: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447)