PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
1_MEPAA 6_ AATVQ 11_ RLPEL 16_ GREDR 21_ ASAPA 26_ AAAAA 31_ AAAAA 36_ AAAAA 41_ LAAAA 46_ GGGRS 51_ PEPAL 56_ TPAAP 61_ SGGNG 66_ SGSGA 71_ REEAP 76_ GEAPP 81_ GPLPG 86_ RAGGA 91_ GRRRR 96_ RGAPQ 101_ PIAGG 106_ AAPVP 111_ GAGGG 116_ ANSLL 121_ LRRGR 126_ LKRNL 131_ SAAAA 136_ AASSS 141_ SSSSA 146_ AAASH 151_ SPGAA 156_ GLPAS 161_ CSASA 166_ SLCTR 171_ SLDRK 176_ TLLLK 181_ HRQTL 186_ QLQPS 191_ DRDWV 196_ RHQLQ 201_ RGCVH 206_ VFDRH 211_ MASTY 216_ LRPVL 221_ CTLDT 226_ TAGEV 231_ AARLL 236_ QLGHK 241_ GGGVV 246_ KVLGQ 251_ GPGAA 256_ AAREP 261_ AEPPP 266_ EAGPR 271_ LAPPE 276_ PRDSE 281_ VPPAR 286_ SAPGA 291_ FGGPP 296_ RAPPA 301_ DLPLP 306_ VGGPG 311_ GWSRR 316_ ASPAP 321_ SDSSP 326_ GEPFV 331_ GGPVS 336_ SPRAP 341_ RPVVS 346_ DTESF 351_ SLSPS 356_ AESVS 361_ DRLDP 366_ YSSGG 371_ GSSSS 376_ SEELE 381_ ADAAS 386_ APTGV 391_ PGQPR 396_ RPGHP 401_ AQPLP 406_ LPQTA 411_ SSPQP 416_ QQKAP 421_ RAIDS 426_ PGGAV 431_ REGSC 436_ EEKAA 441_ AAVAP 446_ GGLQS 451_ TPGRS 456_ GVTAE 461_ KAPPP 466_ PPPPT 471_ LYVQL 476_ HGETT 481_ RRLEA 486_ EEKPL 491_ QIQND 496_ YLFQL 501_ GFGEL 506_ WRVQE 511_ EGMDS 516_ EIGCL 521_ IRFYA 526_ GKPHS 531_ TGSSE 536_ RIQLS 541_ GMYNV 546_ RKGKM 551_ QLPVN 556_ RWTRR 561_ QVILC 566_ GTCLI 571_ VSSVK 576_ DSLTG 581_ KMHVL 586_ PLIGG 591_ KVEEV 596_ KKHQH 601_ CLAFS 606_ SSGPQ 611_ SQTYY 616_ ICFDT 621_ FTEYL 626_ RWLRQ 631_ VSKVA 636_ SQRIS 641_ SVDLS 646_ CCSLE 651_ HLPAN 656_ LFYSQ 661_ DLTHL 666_ NLKQN 671_ FLRQN 676_ PSLPA 681_ ARGLN 686_ ELQRF 691_ TKLKS 696_ LNLSN 701_ NHLGD 706_ FPLAV 711_ CSIPT 716_ LAELN 721_ VSCNA 726_ LRSVP 731_ AAVGV 736_ MHNLQ 741_ TFLLD 746_ GNFLQ 751_ SLPAE 756_ LENMK 761_ QLSYL 766_ GLSFN 771_ EFTDI 776_ PEVLE 781_ KLTAV 786_ DKLCM 791_ SGNCV 796_ ETLRL 801_ QALRK 806_ MPHIK 811_ HVDLR 816_ LNVIR 821_ KLIAD 826_ EVDFL 831_ QHVTQ 836_ LDLRD 841_ NKLGD 846_ LDAMI 851_ FNNIE 856_ VLHCE 861_ RNQLV 866_ TLDIC 871_ GYFLK 876_ ALYAS 881_ SNELV 886_ QLDVY 891_ PVPNY 896_ LSYMD 901_ VSRNR 906_ LENVP 911_ EWVCE 916_ SRKLE 921_ VLDIG 926_ HNQIC 931_ ELPAR 936_ LFCNS 941_ SLRKL 946_ LAGHN 951_ QLARL 956_ PERLE 961_ RTSVE 966_ VLDVQ 971_ HNQLL 976_ ELPPN 981_ LLMKA 986_ DSLRF 991_ LNASA 996_ NKLES 1001_ LPPAT 1006_ LSEET 1011_ NSILQ 1016_ ELYLT 1021_ NNSLT 1026_ DKCVP 1031_ LLTGH 1036_ PHLKI 1041_ LHMAY 1046_ NRLQS 1051_ FPASK 1056_ MAKLE 1061_ ELEEI 1066_ DLSGN 1071_ KLKAI 1076_ PTTIM 1081_ NCRRM 1086_ HTVIA 1091_ HSNCI 1096_ EVFPE 1101_ VMQLP 1106_ EIKCV 1111_ DLSCN 1116_ ELSEV 1121_ TLPEN 1126_ LPPKL 1131_ QELDL 1136_ TGNPR 1141_ LVLDH 1146_ KTLEL 1151_ LNNIR 1156_ CFKID 1161_ QPSTG 1166_ DASGA 1171_ PAVWS 1176_ HGYTE 1181_ ASGVK 1186_ NKLCV 1191_ AALSV 1196_ NNFCD 1201_ NREAL 1206_ YGVFD 1211_ GDRNV 1216_ EVPYL 1221_ LQCTM 1226_ SDILA 1231_ EELQK 1236_ TKNEE 1241_ EYMVN 1246_ TFIVM 1251_ QRKLG 1256_ TAGQK 1261_ LGGAA 1266_ VLCHI 1271_ KHDPV 1276_ DPGGS 1281_ FTLTS 1286_ ANVGK 1291_ CQTVL 1296_ CRNGK 1301_ PLPLS 1306_ RSYIM 1311_ SCEEE 1316_ LKRIK 1321_ QHKAI 1326_ ITEDG 1331_ KVNGV 1336_ TESTR 1341_ ILGYT 1346_ FLHPS 1351_ VVPRP 1356_ HVQSV 1361_ LLTPQ 1366_ DEFFI 1371_ LGSKG 1376_ LWDSL 1381_ SVEEA 1386_ VEAVR 1391_ NVPDA 1396_ LAAAK 1401_ KLCTL 1406_ AQSYG 1411_ CHDSI 1416_ SAVVV 1421_ QLSVT 1426_ EDSFC 1431_ CCELS 1436_ AGGAV 1441_ PPPSP 1446_ GIFPP 1451_ SVNMV 1456_ IKDRP 1461_ SDGLG 1466_ VPSSS 1471_ SGMAS 1476_ EISSE 1481_ LSTSE 1486_ MSSEV 1491_ GSTAS 1496_ DEPPP 1501_ GALSE 1506_ NSPAY 1511_ PSEQR 1516_ CMLHP 1521_ ICLSN 1526_ SFQRQ 1531_ LSSAT 1536_ FSSAF 1541_ SDNGL 1546_ DSDDE 1551_ EPIEG 1556_ VFTNG 1561_ SRVEV 1566_ EVDIH 1571_ CSRAK 1576_ EKEKQ 1581_ QHLLQ 1586_ VPAEA 1591_ SDEGI 1596_ VISAN 1601_ EDEPG 1606_ LPRKA 1611_ DFSAV 1616_ GTIGR 1621_ RRANG 1626_ SVAPQ 1631_ ERSHN 1636_ VIEVA 1641_ TDAPL 1646_ RKPGG 1651_ YFAAP 1656_ AQPDP 1661_ DDQFI 1666_ IPPEL 1671_ EEEVK 1676_ EIMKH 1681_ HQEQQ 1686_ QQQQP 1691_ PPPPQ 1696_ LQPQL 1701_ PRHYQ 1706_ LDQLP 1711_DYYDT
1: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity)