Voltage-dependent calcium channel gamma-3 subunit (Neuronal voltage-gated calcium channel gamma-3 subunit) (Transmembrane AMPAR regulatory protein gamma-3) (TARP gamma-3)
1_MRMCD 6_ RGIQM 11_ LITTV 16_ GAFAA 21_ FSLMT 26_ IAVGT 31_ DYWLY 36_ SRGVC 41_ RTKST 46_ SDNET 51_ SRKNE 56_ EVMTH 61_ SGLWR 66_ TCCLE 71_ GAFRG 76_ VCKKI 81_ DHFPE 86_ DADYE 91_ QDTAE 96_ YLLRA 101_ VRASS 106_ VFPIL 111_ SVTLL 116_ FFGGL 121_ CVAAS 126_ EFHRS 131_ RHNVI 136_ LSAGI 141_ FFVSA 146_ GLSNI 151_ IGIIV 156_ YISAN 161_ AGDPG 166_ QRDSK 171_ KSYSY 176_ GWSFY 181_ FGAFS 186_ FIIAE 191_ IVGVV 196_ AVHIY 201_ IEKHQ 206_ QLRAK 211_ SHSEF 216_ LKKST 221_ FARLP 226_ PYRYR 231_ FRRRS 236_ SSRST 241_ EPRSR 246_ DLSPI 251_ SKGFH 256_ TIPST 261_ DISMF 266_ TLSRD 271_ PSKIT 276_ MGTLL 281_ NSDRD 286_ HAFLQ 291_ FHNST 296_ PKEFK 301_ ESLHN 306_NPANR
1: Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state