Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein)
1_MRPER 6_ PRPRG 11_ SAPGP 16_ METPP 21_ WDPAR 26_ NDSLP 31_ PTLTP 36_ AVPPY 41_ VKLGL 46_ TVVYT 51_ VFYAL 56_ LFVFI 61_ YVQLW 66_ LVLRY 71_ RHKRL 76_ SYQSV 81_ FLFLC 86_ LFWAS 91_ LRTVL 96_ FSFYF 101_ KDFVA 106_ ANSLS 111_ PFVFW 116_ LLYCF 121_ PVCLQ 126_ FFTLT 131_ LMNLY 136_ FTQVI 141_ FKAKS 146_ KYSPE 151_ LLKYR 156_ LPLYL 161_ ASLFI 166_ SLVFL 171_ LVNLT 176_ CAVLV 181_ KTGNW 186_ ERKVI 191_ VSVRV 196_ AINDT 201_ LFVLC 206_ AVSLS 211_ ICLYK 216_ ISKMS 221_ LANIY 226_ LESKG 231_ SSVCQ 236_ VTAIG 241_ VTVIL 246_ LYTSR 251_ ACYNL 256_ FILSF 261_ SQNKS 266_ VHSFD 271_ YDWYN 276_ VSDQA 281_ DLKNQ 286_ LGDAG 291_ YVLFG 296_ VVLFV 301_ WELLP 306_ TTLVV 311_ YFFRV 316_ RNPTK 321_ DLTNP 326_ GMVPS 331_ HGFSP 336_ RSYFF 341_ DNPRR 346_ YDSDD 351_ DLAWN 356_ IAPQG 361_ LQGGF 366_ APDYY 371_ DWGQQ 376_ TNSFL 381_ AQAGT 386_ LQDST 391_LDPDK
1: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939)
2: Also acts as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity)