Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4)
1_MKLKL 6_ NVLTI 11_ ILLPV 16_ HLLIT 21_ IYSAL 26_ IFIPW 31_ YFLTN 36_ AKKKN 41_ AMAKR 46_ IKAKP 51_ TSDKP 56_ GSPYR 61_ SVTHF 66_ DSLAV 71_ IDIPG 76_ ADTLD 81_ KLFDH 86_ AVSKF 91_ GKKDS 96_ LGTRE 101_ ILSEE 106_ NEMQP 111_ NGKVF 116_ KKLIL 121_ GNYKW 126_ MNYLE 131_ VNRRV 136_ NNFGS 141_ GLTAL 146_ GLKPK 151_ NTIAI 156_ FCETR 161_ AEWMI 166_ AAQTC 171_ FKYNF 176_ PLVTL 181_ YATLG 186_ KEAVV 191_ HGLNE 196_ SEASY 201_ LITSV 206_ ELLES 211_ KLKTA 216_ LLDIS 221_ CVKHI 226_ IYVDN 231_ KAINK 236_ AEYPE 241_ GFEIH 246_ SMQSV 251_ EELGS 256_ NPENL 261_ GIPPS 266_ RPTPS 271_ DMAIV 276_ MYTSG 281_ STGRP 286_ KGVMM 291_ HHSNL 296_ IAGMT 301_ GQCER 306_ IPGLG 311_ PKDTY 316_ IGYLP 321_ LAHVL 326_ ELTAE 331_ ISCFT 336_ YGCRI 341_ GYSSP 346_ LTLSD 351_ QSSKI 356_ KKGSK 361_ GDCTV 366_ LKPTL 371_ MAAVP 376_ EIMDR 381_ IYKNV 386_ MSKVQ 391_ EMNYI 396_ QKTLF 401_ KIGYD 406_ YKLEQ 411_ IKKGY 416_ DAPLC 421_ NLLLF 426_ KKVKA 431_ LLGGN 436_ VRMML 441_ SGGAP 446_ LSPQT 451_ HRFMN 456_ VCFCC 461_ PIGQG 466_ YGLTE 471_ SCGAG 476_ TVTEV 481_ TDYTT 486_ GRVGA 491_ PLICC 496_ EIKLK 501_ DWQEG 506_ GYTIN 511_ DKPNP 516_ RGEIV 521_ IGGQN 526_ ISMGY 531_ FKNEE 536_ KTAED 541_ YSVDE 546_ NGQRW 551_ FCTGD 556_ IGEFH 561_ PDGCL 566_ QIIDR 571_ KKDLV 576_ KLQAG 581_ EYVSL 586_ GKVEA 591_ ALKNC 596_ PLIDN 601_ ICAFA 606_ KSDQS 611_ YVISF 616_ VVPNQ 621_ KRLTL 626_ LAQQK 631_ GVEGT 636_ WVDIC 641_ NNPAM 646_ EAEIL 651_ KEIRE 656_ AANAM 661_ KLERF 666_ EIPIK 671_ VRLSP 676_ EPWTP 681_ ETGLV 686_ TDAFK 691_ LKRKE 696_ LRNHY 701_ LKDIE 706_RMYGG
1: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590)