Sorting nexin-3 (Protein SDP3)
1_MAETV 6_ ADTRR 11_ LITKP 16_ QNLND 21_ AYGPP 26_ SNFLE 31_ IDVSN 36_ PQTVG 41_ VGRGR 46_ FTTYE 51_ IRVKT 56_ NLPIF 61_ KLKES 66_ TVRRR 71_ YSDFE 76_ WLRSE 81_ LERES 86_ KVVVP 91_ PLPGK 96_ AFLRQ 101_ LPFRG 106_ DDGIF 111_ DDNFI 116_ EERKQ 121_ GLEQF 126_ INKVA 131_ GHPLA 136_ QNERC 141_ LHMFL 146_ QDEII 151_ DKSYT 156_PSKIR
1: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282, PubMed:30213940). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551)