Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor)
1_MMNMS 6_ LPFLW 11_ SLLTL 16_ LIFAE 21_ VNGEA 26_ GELEL 31_ QRQKR 36_ SINLQ 41_ QPRMA 46_ TERGN 51_ LVFLT 56_ GSAQN 61_ IEFRT 66_ GSLGK 71_ IKLND 76_ EDLSE 81_ CLHQI 86_ QKNKE 91_ DIIEL 96_ KGSAI 101_ GLPQN 106_ ISSQI 111_ YQLNS 116_ KLVDL 121_ ERKFQ 126_ GLQQT 131_ VDKKV 136_ CSSNP 141_ CQNGG 146_ TCLNL 151_ HDSFF 156_ CICPP 161_ QWKGP 166_ LCSAD 171_ VNECE 176_ IYSGT 181_ PLSCQ 186_ NGGTC 191_ VNTMG 196_ SYSCH 201_ CPPET 206_ YGPQC 211_ ASKYD 216_ DCEGG 221_ SVARC 226_ VHGIC 231_ EDLMR 236_ EQAGE 241_ PKYSC 246_ VCDAG 251_ WMFSP 256_ NSPAC 261_ TLDRD 266_ ECSFQ 271_ PGPCS 276_ TLVQC 281_ FNTQG 286_ SFYCG 291_ ACPTG 296_ WQGNG 301_ YICED 306_ INECE 311_ INNGG 316_ CSVAP 321_ PVECV 326_ NTPGS 331_ SHCQA 336_ CPPGY 341_ QGDGR 346_ VCTLT 351_ DICSV 356_ SNGGC 361_ HPDAS 366_ CSSTL 371_ GSLPL 376_ CTCLP 381_ GYTGN 386_ GYGPN 391_ GCVQL 396_ SNICL 401_ SHPCL 406_ NGQCI 411_ DTVSG 416_ YFCKC 421_ DSGWT 426_ GVNCT 431_ ENINE 436_ CLSNP 441_ CLNGG 446_ TCVDG 451_ VDSFS 456_ CECTR 461_ LWTGA 466_ LCQVP 471_ QQVCG 476_ ESLSG 481_ INGSF 486_ SYRSP 491_ DVGYV 496_ HDVNC 501_ FWVIK 506_ TEMGK 511_ VLRIT 516_ FTFFR 521_ LESMD 526_ NCPHE 531_ FLQVY 536_ DGDSS 541_ SAFQL 546_ GRFCG 551_ SSLPH 556_ ELLSS 561_ DNALY 566_ FHLYS 571_ EHLRN 576_ GRGFT 581_ VRWET 586_ QQPEC 591_ GGILT 596_ GPYGS 601_ IKSPG 606_ YPGNY 611_ PPGRD 616_ CVWIV 621_ VTSPD 626_ LLVTF 631_ TFGTL 636_ SLEHH 641_ DDCNK 646_ DYLEI 651_ RDGPL 656_ YQDPL 661_ LGKFC 666_ TTFSV 671_ PPLQT 676_ TGPFA 681_ RIHFH 686_ SDSQI 691_ SDQGF 696_ HITYL 701_ TSPSD 706_ LRCGG 711_ NYTDP 716_ EGELF 721_ LPELS 726_ GPFTH 731_ TRQCV 736_ YMMKQ 741_ PQGEQ 746_ IQINF 751_ THVEL 756_ QCQSD 761_ SSQNY 766_ IEVRD 771_ GETLL 776_ GKVCG 781_ NGTIS 786_ HIKSI 791_ TNSVW 796_ IRFKI 801_ DASVE 806_ KASFR 811_ AVYQV 816_ ACGDE 821_ LTGEG 826_ VIRSP 831_ FFPNV 836_ YPGER 841_ TCRWT 846_ IHQPQ 851_ SQVIL 856_ LNFTV 861_ FEIGS 866_ SAHCE 871_ TDYVE 876_ IGSSS 881_ ILGSP 886_ ENKKY 891_ CGTDI 896_ PSFIT 901_ SVYNF 906_ LYVTF 911_ VKSSS 916_ TENHG 921_ FMAKF 926_ SAEDL 931_ ACGEI 936_ LTEST 941_ GTIQS 946_ PGHPN 951_ VYPHG 956_ INCTW 961_ HILVQ 966_ PNHLI 971_ HLMFE 976_ TFHLE 981_ FHYNC 986_ TNDYL 991_ EVYDT 996_ DSETS 1001_ LGRYC 1006_ GKSIP 1011_ PSLTS 1016_ SGNSL 1021_ MLVFV 1026_ TDSDL 1031_ AYEGF 1036_ LINYE 1041_ AISAA 1046_ TACLQ 1051_ DYTDD 1056_ LGTFT 1061_ SPNFP 1066_ NNYPN 1071_ NWECI 1076_ YRITV 1081_ RTGQL 1086_ IAVHF 1091_ TNFSL 1096_ EEAIG 1101_ NYYTD 1106_ FLEIR 1111_ DGGYE 1116_ KSPLL 1121_ GIFYG 1126_ SNLPP 1131_ TIISH 1136_ SNKLW 1141_ LKFKS 1146_ DQIDT 1151_ RSGFS 1156_ AYWDG 1161_ SSTGC 1166_ GGNLT 1171_ TSSGT 1176_ FISPN 1181_ YPMPY 1186_ YHSSE 1191_ CYWWL 1196_ KSSHG 1201_ SAFEL 1206_ EFKDF 1211_ HLEHH 1216_ PNCTL 1221_ DYLAV 1226_ YDGPS 1231_ SNSHL 1236_ LTQLC 1241_ GDEKP 1246_ PLIRS 1251_ SGDSM 1256_ FIKLR 1261_ TDEGQ 1266_ QGRGF 1271_ KAEYR 1276_ QTCEN 1281_ VVIVN 1286_ QTYGI 1291_ LESIG 1296_ YPNPY 1301_ SENQH 1306_ CNWTI 1311_ RATTG 1316_ NTVNY 1321_ TFLAF 1326_ DLEHH 1331_ INCST 1336_ DYLEL 1341_ YDGPR 1346_ QMGRY 1351_ CGVDL 1356_ PPPGS 1361_ TTSSK 1366_ LQVLL 1371_ LTDGV 1376_ GRREK 1381_ GFQMQ 1386_ WFVYG 1391_ CGGEL 1396_ SGATG 1401_ SFSSP 1406_ GFPNR 1411_ YPPNK 1416_ ECIWY 1421_ IRTDP 1426_ GSSIQ 1431_ LTIHD 1436_ FDVEY 1441_ HSRCN 1446_ FDVLE 1451_ IYGGP 1456_ DFHSP 1461_ RIAQL 1466_ CTQRS 1471_ PENPM 1476_ QVSST 1481_ GNELA 1486_ IRFKT 1491_ DLSIN 1496_ GRGFN 1501_ ASWQA 1506_ VTGGC 1511_ GGIFQ 1516_ APSGE 1521_ IHSPN 1526_ YPSPY 1531_ RSNTD 1536_ CSWVI 1541_ RVDRN 1546_ HRVLL 1551_ NFTDF 1556_ DLEPQ 1561_ DSCIM 1566_ AYDGL 1571_ SSTMS 1576_ RLART 1581_ CGREQ 1586_ LANPI 1591_ VSSGN 1596_ SLFLR 1601_ FQSGP 1606_ SRQNR 1611_ GFRAQ 1616_ FRQAC 1621_ GGHIL 1626_ TSSFD 1631_ TVSSP 1636_ RFPAN 1641_ YPNNQ 1646_ NCSWI 1651_ IQAQP 1656_ PLNHI 1661_ TLSFT 1666_ HFELE 1671_ RSTTC 1676_ ARDFV 1681_ EILDG 1686_ GHEDA 1691_ PLRGR 1696_ YCGTD 1701_ MPHPI 1706_ TSFSS 1711_ ALTLR 1716_ FVSDS 1721_ SISAG 1726_ GFHTT 1731_ VTASV 1736_ SACGG 1741_ TFYMA 1746_ EGIFN 1751_ SPGYP 1756_ DIYPP 1761_ NVECV 1766_ WNIVS 1771_ SPGNR 1776_ LQLSF 1781_ ISFQL 1786_ EDSQD 1791_ CSRDF 1796_ VEIRE 1801_ GNATG 1806_ HLVGR 1811_ YCGNS 1816_ FPLNY 1821_ SSIVG 1826_ HTLWV 1831_ RFISD 1836_ GSGSG 1841_ TGFQA 1846_ TFMKI 1851_ FGNDN 1856_ IVGTH 1861_ GKVAS 1866_ PFWPE 1871_ NYPHN 1876_ SNYQW 1881_ TVNVN 1886_ ASHVV 1891_ HGRIL 1896_ EMDIE 1901_ EIQNC 1906_ YYDKL 1911_ RIYDG 1916_ PSIHA 1921_ RLIGA 1926_ YCGTQ 1931_ TESFS 1936_ STGNS 1941_ LTFHF 1946_ YSDSS 1951_ ISGKG 1956_ FLLEW 1961_ FAVDA 1966_ PDGVL 1971_ PTIAP 1976_ GACGG 1981_ FLRTG 1986_ DAPVF 1991_ LFSPG 1996_ WPDSY 2001_ SNRVD 2006_ CTWLI 2011_ QAPDS 2016_ TVELN 2021_ ILSLD 2026_ IESHR 2031_ TCAYD 2036_ SLVIR 2041_ DGDNN 2046_ LAQQL 2051_ AVLCG 2056_ REIPG 2061_ PIRST 2066_ GEYMF 2071_ IRFTS 2076_ DSSVT 2081_ RAGFN 2086_ ASFHK 2091_ SCGGY 2096_ LHADR 2101_ GIITS 2106_ PKYPE 2111_ TYPSN 2116_ LNCSW 2121_ HVLVQ 2126_ SGLTI 2131_ AVHFE 2136_ QPFQI 2141_ PNGDS 2146_ SCNQG 2151_ DYLVL 2156_ RNGPD 2161_ ICSPP 2166_ LGPPG 2171_ GNGHF 2176_ CGSHA 2181_ SSTLF 2186_ TSDNQ 2191_ MFVQF 2196_ ISDHS 2201_ NEGQG 2206_ FKIKY 2211_ EAKSL 2216_ ACGGN 2221_ VYIHD 2226_ ADSAG 2231_ YVTSP 2236_ NHPHN 2241_ YPPHA 2246_ DCIWI 2251_ LAAPP 2256_ ETRIQ 2261_ LQFED 2266_ RFDIE 2271_ VTPNC 2276_ TSNYL 2281_ ELRDG 2286_ VDSDA 2291_ PILSK 2296_ FCGTS 2301_ LPSSQ 2306_ WSSGE 2311_ VMYLR 2316_ FRSDN 2321_ SPTHV 2326_ GFKAK 2331_ YSIAQ 2336_ CGGRV 2341_ PGQSG 2346_ VVESI 2351_ GHPTL 2356_ PYRDN 2361_ LFCEW 2366_ HLQGL 2371_ SGHYL 2376_ TISFE 2381_ DFNLQ 2386_ NSSGC 2391_ EKDFV 2396_ EIWDN 2401_ HTSGN 2406_ ILGRY 2411_ CGNTI 2416_ PDSID 2421_ TSSNT 2426_ AVVRF 2431_ VTDGS 2436_ VTASG 2441_ FRLRF 2446_ ESSME 2451_ ECGGD 2456_ LQGSI 2461_ GTFTS 2466_ PNYPN 2471_ PNPHG 2476_ RICEW 2481_ RITAP 2486_ EGRRI 2491_ TLMFN 2496_ NLRLA 2501_ THPSC 2506_ NNEHV 2511_ IVFNG 2516_ IRSNS 2521_ PQLEK 2526_ LCSSV 2531_ NVSNE 2536_ IKSSG 2541_ NTMKV 2546_ IFFTD 2551_ GSRPY 2556_ GGFTA 2561_ SYTSS 2566_ EDAVC 2571_ GGSLP 2576_ NTPEG 2581_ NFTSP 2586_ GYDGV 2591_ RNYSR 2596_ NLNCE 2601_ WTLSN 2606_ PNQGN 2611_ SSISI 2616_ HFEDF 2621_ YLESH 2626_ QDCQF 2631_ DVLEF 2636_ RVGDA 2641_ DGPLM 2646_ WRLCG 2651_ PSKPT 2656_ LPLVI 2661_ PYSQV 2666_ WIHFV 2671_ TNERV 2676_ EHIGF 2681_ HAKYS 2686_ FTDCG 2691_ GIQIG 2696_ DSGVI 2701_ TSPNY 2706_ PNAYD 2711_ SLTHC 2716_ SSLLE 2721_ APQGH 2726_ TITLT 2731_ FSDFD 2736_ IEPHT 2741_ TCAWD 2746_ SVTVR 2751_ NGGSP 2756_ ESPII 2761_ GQYCG 2766_ NSNPR 2771_ TIQSG 2776_ SNQLV 2781_ VTFNS 2786_ DHSLQ 2791_ GGGFY 2796_ ATWNT 2801_ QTLGC 2806_ GGIFH 2811_ SDNGT 2816_ IRSPH 2821_ WPQNF 2826_ PENSR 2831_ CSWTA 2836_ ITHKS 2841_ KHLEI 2846_ SFDNN 2851_ FLIPS 2856_ GDGQC 2861_ QNSFV 2866_ KVWAG 2871_ TEEVD 2876_ KALLA 2881_ TGCGN 2886_ VAPGP 2891_ VITPS 2896_ NTFTA 2901_ VFQSQ 2906_ EAPAQ 2911_ GFSAS 2916_ FVSRC 2921_ GSNFT 2926_ GPSGY 2931_ IISPN 2936_ YPKQY 2941_ DNNMN 2946_ CTYVI 2951_ EANPL 2956_ SVVLL 2961_ TFVSF 2966_ HLEAR 2971_ SAVTG 2976_ SCVND 2981_ GVHII 2986_ RGYSV 2991_ MSTPF 2996_ ATVCG 3001_ DEMPA 3006_ PLTIA 3011_ GPVLL 3016_ NFYSN 3021_ EQITD 3026_ FGFKF 3031_ SYRII 3036_ SCGGV 3041_ FNFSS 3046_ GIITS 3051_ PAYSY 3056_ ADYPN 3061_ DMHCL 3066_ YTITV 3071_ SDDKV 3076_ IELKF 3081_ SDFDV 3086_ VPSTS 3091_ CSHDY 3096_ LAIYD 3101_ GANTS 3106_ DPLLG 3111_ KFCGS 3116_ KRPPN 3121_ VKSSN 3126_ NSMLL 3131_ VFKTD 3136_ SFQTA 3141_ KGWKM 3146_ SFRQT 3151_ LGPQQ 3156_ GCGGY 3161_ LTGSN 3166_ NTFAS 3171_ PDSDS 3176_ NGMYD 3181_ KNLNC 3186_ VWIII 3191_ APVNK 3196_ VIHLT 3201_ FNTFA 3206_ LEAAS 3211_ TRQRC 3216_ LYDYV 3221_ KLYDG 3226_ DSENA 3231_ NLAGT 3236_ FCGST 3241_ VPAPF 3246_ ISSGN 3251_ FLTVQ 3256_ FISDL 3261_ TLERE 3266_ GFNAT 3271_ YTIMD 3276_ MPCGG 3281_ TYNAT 3286_ WTPQN 3291_ ISSPN 3296_ SSDPD 3301_ VPFSI 3306_ CTWVI 3311_ DSPPH 3316_ QQVKI 3321_ TVWAL 3326_ QLTSQ 3331_ DCTQN 3336_ YLQLQ 3341_ DSPQG 3346_ HGNSR 3351_ FQFCG 3356_ RNASA 3361_ VPVFY 3366_ SSMST 3371_ AMVIF 3376_ KSGVV 3381_ NRNSR 3386_ MSFTY 3391_ QIADC 3396_ NRDYH 3401_ KAFGN 3406_ LRSPG 3411_ WPDNY 3416_ DNDKD 3421_ CTVTL 3426_ TAPQN 3431_ HTISL 3436_ FFHSL 3441_ GIENS 3446_ VECRN 3451_ DFLEV 3456_ RNGSN 3461_ SNSPL 3466_ LGKYC 3471_ GTLLP 3476_ NPVFS 3481_ QNNEL 3486_ YLRFK 3491_ SDSVT 3496_ SDRGY 3501_ EIIWT 3506_ SSPSG 3511_ CGGTL 3516_ YGDRG 3521_ SFTSP 3526_ GYPGT 3531_ YPNNT 3536_ YCEWV 3541_ LVAPA 3546_ GRLVT 3551_ INFYF 3556_ ISIDD 3561_ PGDCV 3566_ QNYLT 3571_ LYDGP 3576_ NASSP 3581_ SSGPY 3586_ CGGDT 3591_ SIAPF 3596_ VASSN 3601_ QVFIK 3606_ FHADY 3611_ ARRPS 3616_AFRLT
1: Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed:10371504, PubMed:11606717, PubMed:11717447, PubMed:14576052, PubMed:9572993). Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex (PubMed:14576052, PubMed:9572993). Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium (PubMed:9572993). Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface