Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
1_MGDGA 6_ VKQGF 11_ LYLQQ 16_ QQTFG 21_ KKWRR 26_ FGASL 31_ YGGSD 36_ CALAR 41_ LELQE 46_ GPEKP 51_ RRCEA 56_ ARKVI 61_ RLSDC 66_ LRVAE 71_ AGGEA 76_ SSPRD 81_ TSAFF 86_ LETKE 91_ RLYLL 96_ AAPAA 101_ ERGDW 106_ VQAIC 111_ LLAFP 116_ GQRKE 121_ LSGPE 126_ GKQSR 131_ PCMEE 136_ NELYS 141_ SAVTV 146_ GPHKE 151_ FAVTM 156_ RPTEA 161_ SERCH 166_ LRGSY 171_ TLRAG 176_ ESALE 181_ LWGGP 186_ EPGTQ 191_ LYDWP 196_ YRFLR 201_ RFGRD 206_ KVTFS 211_ FEAGR 216_ RCVSG 221_ EGNFE 226_ FETRQ 231_ GNEIF 236_ LALEE 241_ AISAQ 246_ KNAAP 251_ ATPQP 256_ QPATI 261_ PASLP 266_ RPDSP 271_ YSRPH 276_ DSLPP 281_ PSPTT 286_ PVPAP 291_ RPRGQ 296_ EGEYA 301_ VPFDA 306_ VARSL 311_ GKNFR 316_ GILAV 321_ PPQLL 326_ ADPLY 331_ DSIEE 336_ TLPPR 341_ PDHIY 346_ DEPEG 351_ VAALS 356_ LYDSP 361_ QEPRG 366_ EAWRR 371_ QATAD 376_ RDPAG 381_ LQHVQ 386_ PAGQD 391_ FSASG 396_ WQPGT 401_ EYDNV 406_VLKKG
1: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity)