Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)
1_MATEH 6_ VNGNG 11_ TEEPM 16_ DTTSA 21_ VIHSE 26_ NFQTL 31_ LDAGL 36_ PQKVA 41_ EKLDE 46_ IYVAG 51_ LVAHS 56_ DLDER 61_ AIEAL 66_ KEFNE 71_ DGALA 76_ VLQQF 81_ KDSDL 86_ SHVQN 91_ KSAFL 96_ CGVMK 101_ TYRQR 106_ EKQGT 111_ KVADS 116_ SKGPD 121_ EAKIK 126_ ALLER 131_ TGYTL 136_ DVTTG 141_ QRKYG 146_ GPPPD 151_ SVYSG 156_ QQPSV 161_ GTEIF 166_ VGKIP 171_ RDLFE 176_ DELVP 181_ LFEKA 186_ GPIWD 191_ LRLMM 196_ DPLTG 201_ LNRGY 206_ AFVTF 211_ CTKEA 216_ AQEAV 221_ KLYNN 226_ HEIRS 231_ GKHIG 236_ VCISV 241_ ANNRL 246_ FVGSI 251_ PKSKT 256_ KEQIL 261_ EEFSK 266_ VTEGL 271_ TDVIL 276_ YHQPD 281_ DKKKN 286_ RGFCF 291_ LEYED 296_ HKTAA 301_ QARRR 306_ LMSGK 311_ VKVWG 316_ NVGTV 321_ EWADP 326_ IEDPD 331_ PEVMA 336_ KVKVL 341_ FVRNL 346_ ANTVT 351_ EEILE 356_ KAFSQ 361_ FGKLE 366_ RVKKL 371_ KDYAF 376_ IHFDE 381_ RDGAV 386_ KAMEE 391_ MNGKD 396_ LEGEN 401_ IEIVF 406_ AKPPD 411_ QKRKE 416_ RKAQR 421_ QAAKN 426_ QMYDD 431_ YYYYG 436_ PPHMP 441_ PPTRG 446_ RGRGG 451_ RGGYG 456_ YPPDY 461_ YGYED 466_ YYDYY 471_ GYDYH 476_ NYRGG 481_ YEDPY 486_ YGYED 491_ FQVGA 496_ RGRGG 501_ RGARG 506_ AAPSR 511_ GRGAA 516_ PPRGR 521_ AGYSQ 526_ RGGPG 531_ SARGV 536_ RGARG 541_ GAQQQ 546_ RGRGV 551_ RGARG 556_ GRGGN 561_ VGGKR 566_ KADGY 571_ NQPDS 576_ KRRQT 581_ NNQNW 586_ GSQPI 591_ AQQPL 596_ QGGDH 601_ SGNYG 606_ YKSEN 611_ QEFYQ 616_DTFGQ
1: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function