Beta-1,4-galactosyltransferase 4 (Beta-1,4-GalTase 4) (Beta4Gal-T4) (b4Gal-T4) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Lactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4)
1_MGFNL 6_ TFHLS 11_ YKFRL 16_ LLLLT 21_ LCLTV 26_ VGWAT 31_ SNYFV 36_ GAIQE 41_ IPKAK 46_ EFMAN 51_ FHKTL 56_ ILGKG 61_ KTLTN 66_ EASTK 71_ KVELD 76_ NCPSV 81_ SPYLR 86_ GQSKL 91_ IFKPD 96_ LTLEE 101_ VQAEN 106_ PKVSR 111_ GRYRP 116_ QECKA 121_ LQRVA 126_ ILVPH 131_ RNREK 136_ HLMYL 141_ LEHLH 146_ PFLQR 151_ QQLDY 156_ GIYVI 161_ HQAEG 166_ KKFNR 171_ AKLLN 176_ VGYLE 181_ ALKEE 186_ NWDCF 191_ IFHDV 196_ DLVPE 201_ NDFNL 206_ YKCEE 211_ HPKHL 216_ VVGRN 221_ STGYR 226_ LRYSG 231_ YFGGV 236_ TALSR 241_ EQFFK 246_ VNGFS 251_ NNYWG 256_ WGGED 261_ DDLRL 266_ RVELQ 271_ RMKIS 276_ RPLPE 281_ VGKYT 286_ MVFHT 291_ RDKGN 296_ EVNAE 301_ RMKLL 306_ HQVSR 311_ VWRTD 316_ GLSSC 321_ SYKLV 326_ SVEHN 331_ PLYIN 336_ITVDF
1: Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids (PubMed:12511560, PubMed:17690104, PubMed:32827291, PubMed:9792633). Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans. Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed:17690104). Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex). May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration (PubMed:12511560). In the biosynthesis pathway of neolacto-series glycosphingolipids, transfers Gal residue via a beta1->4 linkage to terminal GlcNAc of a lactotriaosylceramide (Lc3Cer) acceptor to form a neolactotetraosylceramide (PubMed:9792633)