Gene name: EIF4EBP3

Uniprot entry:

O60516

Protein names:

Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3)

Protein sequence:

1_MSTST 6_ SCPIP 11_ GGRDQ 16_ LPDCY 21_ STTPG 26_ GTLYA 31_ TTPGG 36_ TRIIY 41_ DRKFL 46_ LECKN 51_ SPIAR 56_ TPPCC 61_ LPQIP 66_ GVTTP 71_ PTAPL 76_ SKLEE 81_ LKEQE 86_ TEEEI 91_PDDAQ

Protein annotations

Protein functions:

1: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:22684010)