Cell death activator CIDE-A (Cell death-inducing DFFA-like effector A)
1_MEAAR 6_ DYAGA 11_ LIRPL 16_ TFMGS 21_ QTKRV 26_ LFTPL 31_ MHPAR 36_ PFRVS 41_ NHDRS 46_ SRRGV 51_ MASSL 56_ QELIS 61_ KTLDA 66_ LVIAT 71_ GLVTL 76_ VLEED 81_ GTVVD 86_ TEEFF 91_ QTLGD 96_ NTHFM 101_ ILEKG 106_ QKWMP 111_ GSQHV 116_ PTCSP 121_ PKRSG 126_ IARVT 131_ FDLYR 136_ LNPKD 141_ FIGCL 146_ NVKAT 151_ MYEMY 156_ SVSYD 161_ IRCTG 166_ LKGLL 171_ RSLLR 176_ FLSYS 181_ AQVTG 186_ QFLIY 191_ LGTYM 196_ LRVLD 201_ DKEER 206_ PSLRS 211_QAKGR
1: Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:19843876, PubMed:26118629). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:19843876). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (By similarity). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (By similarity). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (By similarity)