Cyclin-T1 (CycT1) (Cyclin-T)
1_MEGER 6_ KNNNK 11_ RWYFT 16_ REQLE 21_ NSPSR 26_ RFGVD 31_ PDKEL 36_ SYRQQ 41_ AANLL 46_ QDMGQ 51_ RLNVS 56_ QLTIN 61_ TAIVY 66_ MHRFY 71_ MIQSF 76_ TQFPG 81_ NSVAP 86_ AALFL 91_ AAKVE 96_ EQPKK 101_ LEHVI 106_ KVAHT 111_ CLHPQ 116_ ESLPD 121_ TRSEA 126_ YLQQV 131_ QDLVI 136_ LESII 141_ LQTLG 146_ FELTI 151_ DHPHT 156_ HVVKC 161_ TQLVR 166_ ASKDL 171_ AQTSY 176_ FMATN 181_ SLHLT 186_ TFSLQ 191_ YTPPV 196_ VACVC 201_ IHLAC 206_ KWSNW 211_ EIPVS 216_ TDGKH 221_ WWEYV 226_ DATVT 231_ LELLD 236_ ELTHE 241_ FLQIL 246_ EKTPN 251_ RLKRI 256_ WNWRA 261_ CEAAK 266_ KTKAD 271_ DRGTD 276_ EKTSE 281_ QTILN 286_ MISQS 291_ SSDTT 296_ IAGLM 301_ SMSTS 306_ TTSAV 311_ PSLPV 316_ SEESS 321_ SNLTS 326_ VEMLP 331_ GKRWL 336_ SSQPS 341_ FKLEP 346_ TQGHR 351_ TSENL 356_ ALTGV 361_ DHSLP 366_ QDGSN 371_ AFISQ 376_ KQNSK 381_ SVPSA 386_ KVSLK 391_ EYRAK 396_ HAEEL 401_ AAQKR 406_ QLENM 411_ EANVK 416_ SQYAY 421_ AAQNL 426_ LSHHD 431_ SHSSV 436_ ILKMP 441_ IEGSE 446_ NPERP 451_ FLEKA 456_ DKTAL 461_ KMRIP 466_ VAGGD 471_ KAASS 476_ KPEEI 481_ KMRIK 486_ VHAAA 491_ DKHNS 496_ VEDSV 501_ TKSRE 506_ HKEKH 511_ KTHPS 516_ NHHHH 521_ HNHHS 526_ HKHSH 531_ SQLPV 536_ GTGNK 541_ RPGDP 546_ KHSSQ 551_ TSNLA 556_ HKTYS 561_ LSSSF 566_ SSSSS 571_ TRKRG 576_ PSEET 581_ GGAVF 586_ DHPAK 591_ IAKST 596_ KSSSL 601_ NFSFP 606_ SLPTM 611_ GQMPG 616_ HSSDT 621_ SGLSF 626_ SQPSC 631_ KTRVP 636_ HSKLD 641_ KGPTG 646_ ANGHN 651_ TTQTI 656_ DYQDT 661_ VNMLH 666_ SLLSA 671_ QGVQP 676_ TQPTA 681_ FEFVR 686_ PYSDY 691_ LNPRS 696_ GGISS 701_ RSGNT 706_ DKPRP 711_ PPLPS 716_ EPPPP 721_LPPLP
1: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539)
2: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes