Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2)
1_MSRTA 6_ YTVGA 11_ LLLLL 16_ GTLLP 21_ AAEGK 26_ KKGSQ 31_ GAIPP 36_ PDKAQ 41_ HNDSE 46_ QTQSP 51_ QQPGS 56_ RNRGR 61_ GQGRG 66_ TAMPG 71_ EEVLE 76_ SSQEA 81_ LHVTE 86_ RKYLK 91_ RDWCK 96_ TQPLK 101_ QTIHE 106_ EGCNS 111_ RTIIN 116_ RFCYG 121_ QCNSF 126_ YIPRH 131_ IRKEE 136_ GSFQS 141_ CSFCK 146_ PKKFT 151_ TMMVT 156_ LNCPE 161_ LQPPT 166_ KKKRV 171_ TRVKQ 176_CRCIS
1: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity)