Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)
1_MAAVK 6_ KEGGA 11_ LSEAM 16_ SLEGD 21_ EWELS 26_ KENVQ 31_ PLRQG 36_ RIMST 41_ LQGAL 46_ AQESA 51_ CNNTL 56_ QQQKR 61_ AFEYE 66_ IRFYT 71_ GNDPL 76_ DVWDR 81_ YISWT 86_ EQNYP 91_ QGGKE 96_ SNMST 101_ LLERA 106_ VEALQ 111_ GEKRY 116_ YSDPR 121_ FLNLW 126_ LKLGR 131_ LCNEP 136_ LDMYS 141_ YLHNQ 146_ GIGVS 151_ LAQFY 156_ ISWAE 161_ EYEAR 166_ ENFRK 171_ ADAIF 176_ QEGIQ 181_ QKAEP 186_ LERLQ 191_ SQHRQ 196_ FQARV 201_ SRQTL 206_ LALEK 211_ EEEEE 216_ VFESS 221_ VPQRS 226_ TLAEL 231_ KSKGK 236_ KTARA 241_ PIIRV 246_ GGALK 251_ APSQN 256_ RGLQN 261_ PFPQQ 266_ MQNNS 271_ RITVF 276_ DENAD 281_ EASTA 286_ ELSKP 291_ TVQPW 296_ IAPPM 301_ PRAKE 306_ NELQA 311_ GPWNT 316_ GRSLE 321_ HRPRG 326_ NTASL 331_ IAVPA 336_ VLPSF 341_ TPYVE 346_ ETARQ 351_ PVMTP 356_ CKIEP 361_ SINHI 366_ LSTRK 371_ PGKEE 376_ GDPLQ 381_ RVQSH 386_ QQASE 391_ EKKEK 396_ MMYCK 401_ EKIYA 406_ GVGEF 411_ SFEEI 416_ RAEVF 421_ RKKLK 426_ EQREA 431_ ELLTS 436_ AEKRA 441_ EMQKQ 446_ IEEME 451_ KKLKE 456_ IQTTQ 461_ QERTG 466_ DQQEE 471_ TMPTK 476_ ETTKL 481_ QIASE 486_ SQKIP 491_ GMTLS 496_ SSVCQ 501_ VNCCA 506_ RETSL 511_ AENIW 516_ QEQPH 521_ SKGPS 526_ VPFSI 531_ FDEFL 536_ LSEKK 541_ NKSPP 546_ ADPPR 551_ VLAQR 556_ RPLAV 561_ LKTSE 566_ SITSN 571_ EDVSP 576_ DVCDE 581_ FTGIE 586_ PLSED 591_ AIITG 596_ FRNVT 601_ ICPNP 606_ EDTCD 611_ FARAA 616_ RFVST 621_ PFHEI 626_ MSLKD 631_ LPSDP 636_ ERLLP 641_ EEDLD 646_ VKTSE 651_ DQQTA 656_ CGTIY 661_ SQTLS 666_ IKKLS 671_ PIIED 676_ SREAT 681_ HSSGF 686_ SGSSA 691_ SVAST 696_ SSIKC 701_ LQIPE 706_ KLELT 711_ NETSE 716_ NPTQS 721_ PWCSQ 726_ YRRQL 731_ LKSLP 736_ ELSAS 741_ AELCI 746_ EDRPM 751_ PKLEI 756_ EKEIE 761_ LGNED 766_ YCIKR 771_ EYLIC 776_ EDYKL 781_ FWVAP 786_ RNSAE 791_ LTVIK 796_ VSSQP 801_ VPWDF 806_ YINLK 811_ LKERL 816_ NEDFD 821_ HFCSC 826_ YQYQD 831_ GCIVW 836_ HQYIN 841_ CFTLQ 846_ DLLQH 851_ SEYIT 856_ HEITV 861_ LIIYN 866_ LLTIV 871_ EMLHK 876_ AEIVH 881_ GDLSP 886_ RCLIL 891_ RNRIH 896_ DPYDC 901_ NKNNQ 906_ ALKIV 911_ DFSYS 916_ VDLRV 921_ QLDVF 926_ TLSGF 931_ RTVQI 936_ LEGQK 941_ ILANC 946_ SSPYQ 951_ VDLFG 956_ IADLA 961_ HLLLF 966_ KEHLQ 971_ VFWDG 976_ SFWKL 981_ SQNIS 986_ ELKDG 991_ ELWNK 996_ FFVRI 1001_ LNAND 1006_ EATVS 1011_ VLGEL 1016_ AAEMN 1021_ GVFDT 1026_ TFQSH 1031_ LNKAL 1036_ WKVGK 1041_LTSPG
1: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression