Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]
1_MTSSG 6_ PGPRF 11_ LLLLP 16_ LLLPP 21_ AASAS 26_ DRPRG 31_ RDPVN 36_ PEKLL 41_ VITVA 46_ TAETE 51_ GYLRF 56_ LRSAE 61_ FFNYT 66_ VRTLG 71_ LGEEW 76_ RGGDV 81_ ARTVG 86_ GGQKV 91_ RWLKK 96_ EMEKY 101_ ADRED 106_ MIIMF 111_ VDSYD 116_ VILAG 121_ SPTEL 126_ LKKFV 131_ QSGSR 136_ LLFSA 141_ ESFCW 146_ PEWGL 151_ AEQYP 156_ EVGTG 161_ KRFLN 166_ SGGFI 171_ GFATT 176_ IHQIV 181_ RQWKY 186_ KDDDD 191_ DQLFY 196_ TRLYL 201_ DPGLR 206_ EKLSL 211_ NLDHK 216_ SRIFQ 221_ NLNGA 226_ LDEVV 231_ LKFDR 236_ NRVRI 241_ RNVAY 246_ DTLPI 251_ VVHGN 256_ GPTKL 261_ QLNYL 266_ GNYVP 271_ NGWTP 276_ EGGCG 281_ FCNQD 286_ RRTLP 291_ GGQPP 296_ PRVFL 301_ AVFVE 306_ QPTPF 311_ LPRFL 316_ QRLLL 321_ LDYPP 326_ DRVTL 331_ FLHNN 336_ EVFHE 341_ PHIAD 346_ SWPQL 351_ QDHFS 356_ AVKLV 361_ GPEEA 366_ LSPGE 371_ ARDMA 376_ MDLCR 381_ QDPEC 386_ EFYFS 391_ LDADA 396_ VLTNL 401_ QTLRI 406_ LIEEN 411_ RKVIA 416_ PMLSR 421_ HGKLW 426_ SNFWG 431_ ALSPD 436_ EYYAR 441_ SEDYV 446_ ELVQR 451_ KRVGV 456_ WNVPY 461_ ISQAY 466_ VIRGD 471_ TLRME 476_ LPQRD 481_ VFSGS 486_ DTDPD 491_ MAFCK 496_ SFRDK 501_ GIFLH 506_ LSNQH 511_ EFGRL 516_ LATSR 521_ YDTEH 526_ LHPDL 531_ WQIFD 536_ NPVDW 541_ KEQYI 546_ HENYS 551_ RALEG 556_ EGIVE 561_ QPCPD 566_ VYWFP 571_ LLSEQ 576_ MCDEL 581_ VAEME 586_ HYGQW 591_ SGGRH 596_ EDSRL 601_ AGGYE 606_ NVPTV 611_ DIHMK 616_ QVGYE 621_ DQWLQ 626_ LLRTY 631_ VGPMT 636_ ESLFP 641_ GYHTK 646_ ARAVM 651_ NFVVR 656_ YRPDE 661_ QPSLR 666_ PHHDS 671_ STFTL 676_ NVALN 681_ HKGLD 686_ YEGGG 691_ CRFLR 696_ YDCVI 701_ SSPRK 706_ GWALL 711_ HPGRL 716_ THYHE 721_ GLPTT 726_ WGTRY 731_IMVSF
1: Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812, PubMed:9582318, PubMed:9724729). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:10934207, PubMed:11896059, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:18834968, PubMed:30089812). Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). Essential for normal biosynthesis and secretion of type IV collagens (Probable) (PubMed:18834968). Essential for normal formation of basement membranes (By similarity)