Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
1_MGDHL 6_ DLLLG 11_ VVLMA 16_ GPVFG 21_ IPSCS 26_ FDGRI 31_ AFYRF 36_ CNLTQ 41_ VPQVL 46_ NTTER 51_ LLLSF 56_ NYIRT 61_ VTASS 66_ FPFLE 71_ QLQLL 76_ ELGSQ 81_ YTPLT 86_ IDKEA 91_ FRNLP 96_ NLRIL 101_ DLGSS 106_ KIYFL 111_ HPDAF 116_ QGLFH 121_ LFELR 126_ LYFCG 131_ LSDAV 136_ LKDGY 141_ FRNLK 146_ ALTRL 151_ DLSKN 156_ QIRSL 161_ YLHPS 166_ FGKLN 171_ SLKSI 176_ DFSSN 181_ QIFLV 186_ CEHEL 191_ EPLQG 196_ KTLSF 201_ FSLAA 206_ NSLYS 211_ RVSVD 216_ WGKCM 221_ NPFRN 226_ MVLEI 231_ LDVSG 236_ NGWTV 241_ DITGN 246_ FSNAI 251_ SKSQA 256_ FSLIL 261_ AHHIM 266_ GAGFG 271_ FHNIK 276_ DPDQN 281_ TFAGL 286_ ARSSV 291_ RHLDL 296_ SHGFV 301_ FSLNS 306_ RVFET 311_ LKDLK 316_ VLNLA 321_ YNKIN 326_ KIADE 331_ AFYGL 336_ DNLQV 341_ LNLSY 346_ NLLGE 351_ LYSSN 356_ FYGLP 361_ KVAYI 366_ DLQKN 371_ HIAII 376_ QDQTF 381_ KFLEK 386_ LQTLD 391_ LRDNA 396_ LTTIH 401_ FIPSI 406_ PDIFL 411_ SGNKL 416_ VTLPK 421_ INLTA 426_ NLIHL 431_ SENRL 436_ ENLDI 441_ LYFLL 446_ RVPHL 451_ QILIL 456_ NQNRF 461_ SSCSG 466_ DQTPS 471_ ENPSL 476_ EQLFL 481_ GENML 486_ QLAWE 491_ TELCW 496_ DVFEG 501_ LSHLQ 506_ VLYLN 511_ HNYLN 516_ SLPPG 521_ VFSHL 526_ TALRG 531_ LSLNS 536_ NRLTV 541_ LSHND 546_ LPANL 551_ EILDI 556_ SRNQL 561_ LAPNP 566_ DVFVS 571_ LSVLD 576_ ITHNK 581_ FICEC 586_ ELSTF 591_ INWLN 596_ HTNVT 601_ IAGPP 606_ ADIYC 611_ VYPDS 616_ FSGVS 621_ LFSLS 626_ TEGCD 631_ EEEVL 636_ KSLKF 641_ SLFIV 646_ CTVTL 651_ TLFLM 656_ TILTV 661_ TKFRG 666_ FCFIC 671_ YKTAQ 676_ RLVFK 681_ DHPQG 686_ TEPDM 691_ YKYDA 696_ YLCFS 701_ SKDFT 706_ WVQNA 711_ LLKHL 716_ DTQYS 721_ DQNRF 726_ NLCFE 731_ ERDFV 736_ PGENR 741_ IANIQ 746_ DAIWN 751_ SRKIV 756_ CLVSR 761_ HFLRD 766_ GWCLE 771_ AFSYA 776_ QGRCL 781_ SDLNS 786_ ALIMV 791_ VVGSL 796_ SQYQL 801_ MKHQS 806_ IRGFV 811_ QKQQY 816_ LRWPE 821_ DFQDV 826_ GWFLH 831_ KLSQQ 836_ ILKKE 841_ KEKKK 846_ DNNIP 851_LQTVA
1: Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:11489966, PubMed:20855887). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity)