Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)
1_MEPPG 6_ GSLGP 11_ GRGTR 16_ DKKKG 21_ RSPDE 26_ LPSAG 31_ GDGGK 36_ SKKFT 41_ LKRLM 46_ ADELE 51_ RFTSM 56_ RIKKE 61_ KEKPN 66_ SAHRN 71_ SSASY 76_ GDDPT 81_ AQSLQ 86_ DVSDE 91_ QVLVL 96_ FEQML 101_ LDMNL 106_ NEEKQ 111_ QPLRE 116_ KDIII 121_ KREMV 126_ SQYLY 131_ TSKAG 136_ MSQKE 141_ SSKSA 146_ MMYIQ 151_ ELRSG 156_ LRDMP 161_ LLSCL 166_ ESLRV 171_ SLNNN 176_ PVSWV 181_ QTFGA 186_ EGLAS 191_ LLDIL 196_ KRLHD 201_ EKEET 206_ AGSYD 211_ SRNKH 216_ EIIRC 221_ LKAFM 226_ NNKFG 231_ IKTML 236_ ETEEG 241_ ILLLV 246_ RAMDP 251_ AVPNM 256_ MIDAA 261_ KLLSA 266_ LCILP 271_ QPEDM 276_ NERVL 281_ EAMTE 286_ RAEMD 291_ EVERF 296_ QPLLD 301_ GLKSG 306_ TTIAL 311_ KVGCL 316_ QLINA 321_ LITPA 326_ EELDF 331_ RVHIR 336_ SELMR 341_ LGLHQ 346_ VLQDL 351_ REIEN 356_ EDMRV 361_ QLNVF 366_ DEQGE 371_ EDSYD 376_ LKGRL 381_ DDIRM 386_ EMDDF 391_ NEVFQ 396_ ILLNT 401_ VKDSK 406_ AEPHF 411_ LSILQ 416_ HLLLV 421_ RNDYE 426_ ARPQY 431_ YKLIE 436_ ECISQ 441_ IVLHK 446_ NGADP 451_ DFKCR 456_ HLQIE 461_ IEGLI 466_ DQMID 471_ KTKVE 476_ KSEAK 481_ AAELE 486_ KKLDS 491_ ELTAR 496_ HELQV 501_ EMKKM 506_ ESDFE 511_ QKLQD 516_ LQGEK 521_ DALHS 526_ EKQQI 531_ ATEKQ 536_ DLEAE 541_ VSQLT 546_ GEVAK 551_ LTKEL 556_ EDAKK 561_ EMASL 566_ SAAAI 571_ TVPPS 576_ VPSRA 581_ PVPPA 586_ PPLPG 591_ DSGTI 596_ IPPPP 601_ APGDS 606_ TTPPP 611_ PPPPP 616_ PPPPP 621_ LPGGV 626_ CISSP 631_ PSLPG 636_ GTAIS 641_ PPPPL 646_ SGDAT 651_ IPPPP 656_ PLPEG 661_ VGIPS 666_ PSSLP 671_ GGTAI 676_ PPPPP 681_ LPGSA 686_ RIPPP 691_ PPPLP 696_ GSAGI 701_ PPPPP 706_ PLPGE 711_ AGMPP 716_ PPPPL 721_ PGGPG 726_ IPPPP 731_ PFPGG 736_ PGIPP 741_ PPPGM 746_ GMPPP 751_ PPFGF 756_ GVPAA 761_ PVLPF 766_ GLTPK 771_ KLYKP 776_ EVQLR 781_ RPNWS 786_ KLVAE 791_ DLSQD 796_ CFWTK 801_ VKEDR 806_ FENNE 811_ LFAKL 816_ TLTFS 821_ AQTKT 826_ SKAKK 831_ DQEGG 836_ EEKKS 841_ VQKKK 846_ VKELK 851_ VLDSK 856_ TAQNL 861_ SIFLG 866_ SFRMP 871_ YQEIK 876_ NVILE 881_ VNEAV 886_ LTESM 891_ IQNLI 896_ KQMPE 901_ PEQLK 906_ MLSEL 911_ KDEYD 916_ DLAES 921_ EQFGV 926_ VMGTV 931_ PRLRP 936_ RLNAI 941_ LFKLQ 946_ FSEQV 951_ ENIKP 956_ EIVSV 961_ TAACE 966_ ELRKS 971_ ESFSN 976_ LLEIT 981_ LLVGN 986_ YMNAG 991_ SRNAG 996_ AFGFN 1001_ ISFLC 1006_ KLRDT 1011_ KSTDQ 1016_ KMTLL 1021_ HFLAE 1026_ LCEND 1031_ YPDVL 1036_ KFPDE 1041_ LAHVE 1046_ KASRV 1051_ SAENL 1056_ QKNLD 1061_ QMKKQ 1066_ ISDVE 1071_ RDVQN 1076_ FPAAT 1081_ DEKDK 1086_ FVEKM 1091_ TSFVK 1096_ DAQEQ 1101_ YNKLR 1106_ MMHSN 1111_ METLY 1116_ KELGE 1121_ YFLFD 1126_ PKKLS 1131_ VEEFF 1136_ MDLHN 1141_ FRNMF 1146_ LQAVK 1151_ ENQKR 1156_ RETEE 1161_ KMRRA 1166_ KLAKE 1171_ KAEKE 1176_ RLEKQ 1181_ QKREQ 1186_ LIDMN 1191_ AEGDE 1196_ TGVMD 1201_ SLLEA 1206_ LQSGA 1211_ AFRRK 1216_ RGPRQ 1221_ ANRKA 1226_ GCAVT 1231_ SLLAS 1236_ ELTKD 1241_ DAMAA 1246_ VPAKV 1251_ SKNSE 1256_ TFPTI 1261_ LEEAK 1266_ELVGR
1: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity)