Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) (Tetraspanin TM4-C)
1_MQCFS 6_ FIKTM 11_ MILFN 16_ LLIFL 21_ CGAAL 26_ LAVGI 31_ WVSID 36_ GASFL 41_ KIFGP 46_ LSSSA 51_ MQFVN 56_ VGYFL 61_ IAAGV 66_ VVFAL 71_ GFLGC 76_ YGAKT 81_ ESKCA 86_ LVTFF 91_ FILLL 96_ IFIAE 101_ VAAAV 106_ VALVY 111_ TTMAE 116_ HFLTL 121_ LVVPA 126_ IKKDY 131_ GSQED 136_ FTQVW 141_ NTTMK 146_ GLKCC 151_ GFTNY 156_ TDFED 161_ SPYFK 166_ ENSAF 171_ PPFCC 176_ NDNVT 181_ NTANE 186_ TCTKQ 191_ KAHDQ 196_ KVEGC 201_ FNQLL 206_ YDIRT 211_ NAVTV 216_ GGVAA 221_ GIGGL 226_ ELAAM 231_ IVSMY 236_LYCNL
1: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:30066932, PubMed:30291375). Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways (By similarity). Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK (PubMed:30291375). Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process (PubMed:21836059)