High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)
1_MGCAP 6_ SIHIS 11_ ERLVA 16_ EDAPS 21_ PAAPP 26_ LSSGG 31_ PRLPQ 36_ GQKTA 41_ ALPRT 46_ RGAGL 51_ LESEL 56_ RDGSG 61_ KKVAV 66_ ADVQF 71_ GPMRF 76_ HQDQL 81_ QVLLV 86_ FTKED 91_ NQCNG 96_ FCRAC 101_ EKAGF 106_ KCTVT 111_ KEAQA 116_ VLACF 121_ LDKHH 126_ DIIII 131_ DHRNP 136_ RQLDA 141_ EALCR 146_ SIRSS 151_ KLSEN 156_ TVIVG 161_ VVRRV 166_ DREEL 171_ SVMPF 176_ ISAGF 181_ TRRYV 186_ ENPNI 191_ MACYN 196_ ELLQL 201_ EFGEV 206_ RSQLK 211_ LRACN 216_ SVFTA 221_ LENSE 226_ DAIEI 231_ TSEDR 236_ FIQYA 241_ NPAFE 246_ TTMGY 251_ QSGEL 256_ IGKEL 261_ GEVPI 266_ NEKKA 271_ DLLDT 276_ INSCI 281_ RIGKE 286_ WQGIY 291_ YAKKK 296_ NGDNI 301_ QQNVK 306_ IIPVI 311_ GQGGK 316_ IRHYV 321_ SIIRV 326_ CNGNN 331_ KAEKI 336_ SECVQ 341_ SDTHT 346_ DNQTG 351_ KHKDR 356_ RKGSL 361_ DVKAV 366_ ASRAT 371_ EVSSQ 376_ RRHSS 381_ MARIH 386_ SMTIE 391_ APITK 396_ VINII 401_ NAAQE 406_ SSPMP 411_ VTEAL 416_ DRVLE 421_ ILRTT 426_ ELYSP 431_ QFGAK 436_ DDDPH 441_ ANDLV 446_ GGLMS 451_ DGLRR 456_ LSGNE 461_ YVLST 466_ KNTQM 471_ VSSNI 476_ ITPIS 481_ LDDVP 486_ PRIAR 491_ AMENE 496_ EYWDF 501_ DIFEL 506_ EAATH 511_ NRPLI 516_ YLGLK 521_ MFARF 526_ GICEF 531_ LHCSE 536_ STLRS 541_ WLQII 546_ EANYH 551_ SSNPY 556_ HNSTH 561_ SADVL 566_ HATAY 571_ FLSKE 576_ RIKET 581_ LDPID 586_ EVAAL 591_ IAATI 596_ HDVDH 601_ PGRTN 606_ SFLCN 611_ AGSEL 616_ AILYN 621_ DTAVL 626_ ESHHA 631_ ALAFQ 636_ LTTGD 641_ DKCNI 646_ FKNME 651_ RNDYR 656_ TLRQG 661_ IIDMV 666_ LATEM 671_ TKHFE 676_ HVNKF 681_ VNSIN 686_ KPLAT 691_ LEENG 696_ ETDKN 701_ QEVIN 706_ TMLRT 711_ PENRT 716_ LIKRM 721_ LIKCA 726_ DVSNP 731_ CRPLQ 736_ YCIEW 741_ AARIS 746_ EEYFS 751_ QTDEE 756_ KQQGL 761_ PVVMP 766_ VFDRN 771_ TCSIP 776_ KSQIS 781_ FIDYF 786_ ITDMF 791_ DAWDA 796_ FVDLP 801_ DLMQH 806_ LDNNF 811_ KYWKG 816_ LDEMK 821_LRNLR
1: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299)