Fas apoptotic inhibitory molecule 3 (IgM Fc fragment receptor) (Regulator of Fas-induced apoptosis Toso)
1_MDFWL 6_ WPLYF 11_ LPVSG 16_ ALRIL 21_ PEVKV 26_ EGELG 31_ GSVTI 36_ KCPLP 41_ EMHVR 46_ IYLCR 51_ EMAGS 56_ GTCGT 61_ VVSTT 66_ NFIKA 71_ EYKGR 76_ VTLKQ 81_ YPRKN 86_ LFLVE 91_ VTQLT 96_ ESDSG 101_ VYACG 106_ AGMNT 111_ DRGKT 116_ QKVTL 121_ NVHSE 126_ YEPSW 131_ EEQPM 136_ PETPK 141_ WFHLP 146_ YLFQM 151_ PAYAS 156_ SSKFV 161_ TRVTT 166_ PAQRG 171_ KVPPV 176_ HHSSP 181_ TTQIT 186_ HRPRV 191_ SRASS 196_ VAGDK 201_ PRTFL 206_ PSTTA 211_ SKISA 216_ LEGLL 221_ KPQTP 226_ SYNHH 231_ TRLHR 236_ QRALD 241_ YGSQS 246_ GREGQ 251_ GFHIL 256_ IPTIL 261_ GLFLL 266_ ALLGL 271_ VVKRA 276_ VERRK 281_ ALSRR 286_ ARRLA 291_ VRMRA 296_ LESSQ 301_ RPRGS 306_ PRPRS 311_ QNNIY 316_ SACPR 321_ RARGA 326_ DAAGT 331_ GEAPV 336_ PGPGA 341_ PLPPA 346_ PLQVS 351_ ESPWL 356_ HAPSL 361_ KTSCE 366_ YVSLY 371_ HQPAA 376_ MMEDS 381_DSDDY
1: High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM (PubMed:19858324, PubMed:22675200, PubMed:36949194, PubMed:37095205). Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (PubMed:21908732, PubMed:28230186). Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways (PubMed:19858324, PubMed:22675200, PubMed:25601920, PubMed:30840890)