Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
1_MGMAC 6_ LTMTE 11_ MEGTS 16_ TSSIY 21_ QNGDI 26_ SGNAN 31_ SMKQI 36_ DPVLQ 41_ VYLYH 46_ SLGKS 51_ EADYL 56_ TFPSG 61_ EYVAE 66_ EICIA 71_ ASKAC 76_ GITPV 81_ YHNMF 86_ ALMSE 91_ TERIW 96_ YPPNH 101_ VFHID 106_ ESTRH 111_ NVLYR 116_ IRFYF 121_ PRWYC 126_ SGSNR 131_ AYRHG 136_ ISRGA 141_ EAPLL 146_ DDFVM 151_ SYLFA 156_ QWRHD 161_ FVHGW 166_ IKVPV 171_ THETQ 176_ EECLG 181_ MAVLD 186_ MMRIA 191_ KENDQ 196_ TPLAI 201_ YNSIS 206_ YKTFL 211_ PKCIR 216_ AKIQD 221_ YHILT 226_ RKRIR 231_ YRFRR 236_ FIQQF 241_ SQCKA 246_ TARNL 251_ KLKYL 256_ INLET 261_ LQSAF 266_ YTEKF 271_ EVKEP 276_ GSGPS 281_ GEEIF 286_ ATIII 291_ TGNGG 296_ IQWSR 301_ GKHKE 306_ SETLT 311_ EQDLQ 316_ LYCDF 321_ PNIID 326_ VSIKQ 331_ ANQEG 336_ SNESR 341_ VVTIH 346_ KQDGK 351_ NLEIE 356_ LSSLR 361_ EALSF 366_ VSLID 371_ GYYRL 376_ TADAH 381_ HYLCK 386_ EVAPP 391_ AVLEN 396_ IQSNC 401_ HGPIS 406_ MDFAI 411_ SKLKK 416_ AGNQT 421_ GLYVL 426_ RCSPK 431_ DFNKY 436_ FLTFA 441_ VEREN 446_ VIEYK 451_ HCLIT 456_ KNENE 461_ EYNLS 466_ GTKKN 471_ FSSLK 476_ DLLNC 481_ YQMET 486_ VRSDN 491_ IIFQF 496_ TKCCP 501_ PKPKD 506_ KSNLL 511_ VFRTN 516_ GVSDV 521_ PTSPT 526_ LQRPT 531_ HMNQM 536_ VFHKI 541_ RNEDL 546_ IFNES 551_ LGQGT 556_ FTKIF 561_ KGVRR 566_ EVGDY 571_ GQLHE 576_ TEVLL 581_ KVLDK 586_ AHRNY 591_ SESFF 596_ EAASM 601_ MSKLS 606_ HKHLV 611_ LNYGV 616_ CVCGD 621_ ENILV 626_ QEFVK 631_ FGSLD 636_ TYLKK 641_ NKNCI 646_ NILWK 651_ LEVAK 656_ QLAWA 661_ MHFLE 666_ ENTLI 671_ HGNVC 676_ AKNIL 681_ LIREE 686_ DRKTG 691_ NPPFI 696_ KLSDP 701_ GISIT 706_ VLPKD 711_ ILQER 716_ IPWVP 721_ PECIE 726_ NPKNL 731_ NLATD 736_ KWSFG 741_ TTLWE 746_ ICSGG 751_ DKPLS 756_ ALDSQ 761_ RKLQF 766_ YEDRH 771_ QLPAP 776_ KWAEL 781_ ANLIN 786_ NCMDY 791_ EPDFR 796_ PSFRA 801_ IIRDL 806_ NSLFT 811_ PDYEL 816_ LTEND 821_ MLPNM 826_ RIGAL 831_ GFSGA 836_ FEDRD 841_ PTQFE 846_ ERHLK 851_ FLQQL 856_ GKGNF 861_ GSVEM 866_ CRYDP 871_ LQDNT 876_ GEVVA 881_ VKKLQ 886_ HSTEE 891_ HLRDF 896_ EREIE 901_ ILKSL 906_ QHDNI 911_ VKYKG 916_ VCYSA 921_ GRRNL 926_ KLIME 931_ YLPYG 936_ SLRDY 941_ LQKHK 946_ ERIDH 951_ IKLLQ 956_ YTSQI 961_ CKGME 966_ YLGTK 971_ RYIHR 976_ DLATR 981_ NILVE 986_ NENRV 991_ KIGDF 996_ GLTKV 1001_ LPQDK 1006_ EYYKV 1011_ KEPGE 1016_ SPIFW 1021_ YAPES 1026_ LTESK 1031_ FSVAS 1036_ DVWSF 1041_ GVVLY 1046_ ELFTY 1051_ IEKSK 1056_ SPPAE 1061_ FMRMI 1066_ GNDKQ 1071_ GQMIV 1076_ FHLIE 1081_ LLKNN 1086_ GRLPR 1091_ PDGCP 1096_ DEIYM 1101_ IMTEC 1106_ WNNNV 1111_ NQRPS 1116_ FRDLA 1121_ LRVDQ 1126_IRDNM
1: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:15690087, PubMed:7615558, PubMed:9657743, PubMed:15899890). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:15690087, PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain (PubMed:9657743). Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). Up-regulates the potassium voltage-gated channel activity of KCNA3 (PubMed:25644777)