Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit)
1_MTTNP 6_ KPNKA 11_ LKVKK 16_ EAGEN 21_ APVLS 26_ DDELV 31_ SMSVR 36_ ELNQH 41_ LRGLT 46_ KEEVT 51_ RLKQR 56_ RRTLK 61_ NRGYA 66_ ASCRI 71_ KRVTQ 76_ KEELE 81_ RQRVE 86_ LQQEV 91_ EKLAR 96_ ENSSM 101_ RLELD 106_ ALRSK 111_ YEALQ 116_ TFART 121_ VARGP 126_ VAPSK 131_ VATTS 136_ VITIV 141_ KSTEL 146_ SSTSV 151_PFSAA
1: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9150357). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357)