Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3)
1_MCSLA 6_ SGATG 11_ GRGAV 16_ ENEED 21_ LPELS 26_ DSGDE 31_ AAWED 36_ EDDAD 41_ LPHGK 46_ QQTPC 51_ LFCNR 56_ LFTSA 61_ EETFS 66_ HCKSE 71_ HQFNI 76_ DSMVH 81_ KHGLE 86_ FYGYI 91_ KLINF 96_ IRLKN 101_ PTVEY 106_ MNSIY 111_ NPVPW 116_ EKEEY 121_ LKPVL 126_ EDDLL 131_ LQFDV 136_ EDLYE 141_ PVSVP 146_ FSYPN 151_ GLSEN 156_ TSVVE 161_ KLKHM 166_ EARAL 171_ SAEAA 176_ LARAR 181_ EDLQK 186_ MKQFA 191_ QDFVM 196_ HTDVR 201_ TCSSS 206_ TSVIA 211_ DLQED 216_ EDGVY 221_ FSSYG 226_ HYGIH 231_ EEMLK 236_ DKIRT 241_ ESYRD 246_ FIYQN 251_ PHIFK 256_ DKVVL 261_ DVGCG 266_ TGILS 271_ MFAAK 276_ AGAKK 281_ VLGVD 286_ QSEIL 291_ YQAMD 296_ IIRLN 301_ KLEDT 306_ ITLIK 311_ GKIEE 316_ VHLPV 321_ EKVDV 326_ IISEW 331_ MGYFL 336_ LFESM 341_ LDSVL 346_ YAKNK 351_ YLAKG 356_ GSVYP 361_ DICTI 366_ SLVAV 371_ SDVNK 376_ HADRI 381_ AFWDD 386_ VYGFK 391_ MSCMK 396_ KAVIP 401_ EAVVE 406_ VLDPK 411_ TLISE 416_ PCGIK 421_ HIDCH 426_ TTSIS 431_ DLEFS 436_ SDFTL 441_ KITRT 446_ SMCTA 451_ IAGYF 456_ DIYFE 461_ KNCHN 466_ RVVFS 471_ TGPQS 476_ TKTHW 481_ KQTVF 486_ LLEKP 491_ FSVKA 496_ GEALK 501_ GKVTV 506_ HKNKK 511_ DPRSL 516_ TVTLT 521_ LNNST 526_QTYGL
1: Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (PubMed:22795084, PubMed:23445220, PubMed:25728001, PubMed:31378783, PubMed:33495566, PubMed:39513743). Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2 (PubMed:22795084). Also appears to methylate other ribosomal proteins (By similarity). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (PubMed:33495566). Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation (PubMed:25728001, PubMed:31378783, PubMed:39513743). Mediates asymmetric arginine dimethylation of histone H4 'Arg-3' (H4R3me2a) in the promoter region of miRNA miR-3648, to promote its transcription and osteogenesis (PubMed:31378783)