Peroxisome biogenesis factor 10 (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69)
1_MAPAA 6_ ASPPE 11_ VIRAA 16_ QKDEY 21_ YRGGL 26_ RSAAG 31_ GALHS 36_ LAGAR 41_ KWLEW 46_ RKEVE 51_ LLSDV 56_ AYFGL 61_ TTLAG 66_ YQTLG 71_ EEYVS 76_ IIQVD 81_ PSRIH 86_ VPSSL 91_ RRGVL 96_ VTLHA 101_ VLPYL 106_ LDKAL 111_ LPLEQ 116_ ELQAD 121_ PDSGR 126_ PLQGS 131_ LGPGG 136_ RGCSG 141_ ARRWM 146_ RHHTA 151_ TLTEQ 156_ QRRAL 161_ LRAVF 166_ VLRQG 171_ LACLQ 176_ RLHVA 181_ WFYIH 186_ GVFYH 191_ LAKRL 196_ TGITY 201_ LRVRS 206_ LPGED 211_ LRARV 216_ SYRLL 221_ GVISL 226_ LHLVL 231_ SMGLQ 236_ LYGFR 241_ QRQRA 246_ RKEWR 251_ LHRGL 256_ SHRRA 261_ SLEER 266_ AVSRN 271_ PLCTL 276_ CLEER 281_ RHPTA 286_ TPCGH 291_ LFCWE 296_ CITAW 301_ CSSKA 306_ ECPLC 311_ REKFP 316_ PQKLI 321_YLRHY
1: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:24662292). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)