Importin subunit alpha-7 (Karyopherin subunit alpha-6)
1_METMA 6_ SPGKD 11_ NYRMK 16_ SYKNN 21_ ALNPE 26_ EMRRR 31_ REEEG 36_ IQLRK 41_ QKREQ 46_ QLFKR 51_ RNVEL 56_ INEEA 61_ AMFDS 66_ LLMDS 71_ YVSST 76_ TGESV 81_ ITREM 86_ VEMLF 91_ SDDSD 96_ LQLAT 101_ TQKFR 106_ KLLSK 111_ EPSPP 116_ IDEVI 121_ NTPRV 126_ VDRFV 131_ EFLKR 136_ NENCT 141_ LQFEA 146_ AWALT 151_ NIASG 156_ TSQQT 161_ KIVIE 166_ AGAVP 171_ IFIEL 176_ LNSDF 181_ EDVQE 186_ QAVWA 191_ LGNIA 196_ GDSSV 201_ CRDYV 206_ LNCSI 211_ LNPLL 216_ TLLTK 221_ STRLT 226_ MTRNA 231_ VWALS 236_ NLCRG 241_ KNPPP 246_ EFAKV 251_ SPCLP 256_ VLSRL 261_ LFSSD 266_ SDLLA 271_ DACWA 276_ LSYLS 281_ DGPNE 286_ KIQAV 291_ IDSGV 296_ CRRLV 301_ ELLMH 306_ NDYKV 311_ ASPAL 316_ RAVGN 321_ IVTGD 326_ DIQTQ 331_ VILNC 336_ SALPC 341_ LLHLL 346_ SSPKE 351_ SIRKE 356_ ACWTI 361_ SNITA 366_ GNRAQ 371_ IQAVI 376_ DANIF 381_ PVLIE 386_ ILQKA 391_ EFRTR 396_ KEAAW 401_ AITNA 406_ TSGGT 411_ PEQIR 416_ YLVSL 421_ GCIKP 426_ LCDLL 431_ TVMDS 436_ KIVQV 441_ ALNGL 446_ ENILR 451_ LGEQE 456_ GKRSG 461_ SGVNP 466_ YCGLI 471_ EEAYG 476_ LDKIE 481_ FLQSH 486_ ENQEI 491_ YQKAF 496_ DLIEH 501_ YFGVE 506_ DDDSS 511_ LAPQV 516_ DETQQ 521_ QFIFQ 526_ QPEAP 531_MEGFQ
1: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus