UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22)
1_MFEIK 6_ KICCI 11_ GAGYV 16_ GGPTC 21_ SVIAH 26_ MCPEI 31_ RVTVV 36_ DVNES 41_ RINAW 46_ NSPTL 51_ PIYEP 56_ GLKEV 61_ VESCR 66_ GKNLF 71_ FSTNI 76_ DDAIK 81_ EADLV 86_ FISVN 91_ TPTKT 96_ YGMGK 101_ GRAAD 106_ LKYIE 111_ ACARR 116_ IVQNS 121_ NGYKI 126_ VTEKS 131_ TVPVR 136_ AAESI 141_ RRIFD 146_ ANTKP 151_ NLNLQ 156_ VLSNP 161_ EFLAE 166_ GTAIK 171_ DLKNP 176_ DRVLI 181_ GGDET 186_ PEGQR 191_ AVQAL 196_ CAVYE 201_ HWVPR 206_ EKILT 211_ TNTWS 216_ SELSK 221_ LAANA 226_ FLAQR 231_ ISSIN 236_ SISAL 241_ CEATG 246_ ADVEE 251_ VATAI 256_ GMDQR 261_ IGNKF 266_ LKASV 271_ GFGGS 276_ CFQKD 281_ VLNLV 286_ YLCEA 291_ LNLPE 296_ VARYW 301_ QQVID 306_ MNDYQ 311_ RRRFA 316_ SRIID 321_ SLFNT 326_ VTDKK 331_ IAILG 336_ FAFKK 341_ DTGDT 346_ RESSS 351_ IYISK 356_ YLMDE 361_ GAHLH 366_ IYDPK 371_ VPREQ 376_ IVVDL 381_ SHPGV 386_ SEDDQ 391_ VSRLV 396_ TISKD 401_ PYEAC 406_ DGAHA 411_ VVICT 416_ EWDMF 421_ KELDY 426_ ERIHK 431_ KMLKP 436_ AFIFD 441_ GRRVL 446_ DGLHN 451_ ELQTI 456_ GFQIE 461_ TIGKK 466_ VSSKR 471_ IPYAP 476_ SGEIP 481_ KFSLQ 486_DPPNK
1: Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716)