Leupaxin
1_MEELD 6_ ALLEE 11_ LERST 16_ LQDSD 21_ EYSNP 26_ APLPL 31_ DQHSR 36_ KETNL 41_ DETSE 46_ ILSIQ 51_ DNTSP 56_ LPAQL 61_ VYTTN 66_ IQELN 71_ VYSEA 76_ QEPKE 81_ SPPPS 86_ KTSAA 91_ AQLDE 96_ LMAHL 101_ TEMQA 106_ KVAVR 111_ ADAGK 116_ KHLPD 121_ KQDHK 126_ ASLDS 131_ MLGGL 136_ EQELQ 141_ DLGIA 146_ TVPKG 151_ HCASC 156_ QKPIA 161_ GKVIH 166_ ALGQS 171_ WHPEH 176_ FVCTH 181_ CKEEI 186_ GSSPF 191_ FERSG 196_ LAYCP 201_ NDYHQ 206_ LFSPR 211_ CAYCA 216_ APILD 221_ KVLTA 226_ MNQTW 231_ HPEHF 236_ FCSHC 241_ GEVFG 246_ AEGFH 251_ EKDKK 256_ PYCRK 261_ DFLAM 266_ FSPKC 271_ GGCNR 276_ PVLEN 281_ YLSAM 286_ DTVWH 291_ PECFV 296_ CGDCF 301_ TSFST 306_ GSFFE 311_ LDGRP 316_ FCELH 321_ YHHRR 326_ GTLCH 331_ GCGQP 336_ ITGRC 341_ ISAMG 346_ YKFHP 351_ EHFVC 356_ AFCLT 361_ QLSKG 366_ IFREQ 371_ NDKTY 376_ CQPCF 381_NKLFP
1: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling