Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B)
1_MKRKS 6_ ERRSS 11_ WAAAP 16_ PCSRR 21_ CSSTS 26_ PGVKK 31_ IRSST 36_ QQDPR 41_ RRDPQ 46_ DDVYL 51_ DITDR 56_ LCFAI 61_ LYSRP 66_ KSASN 71_ VHYFS 76_ IDNEL 81_ EYENF 86_ YADFG 91_ PLNLA 96_ MVYRY 101_ CCKIN 106_ KKLKS 111_ ITMLR 116_ KKIVH 121_ FTGSD 126_ QRKQA 131_ NAAFL 136_ VGCYM 141_ VIYLG 146_ RTPEE 151_ AYRIL 156_ IFGET 161_ SYIPF 166_ RDAAY 171_ GSCNF 176_ YITLL 181_ DCFHA 186_ VKKAM 191_ QYGFL 196_ NFNSF 201_ NLDEY 206_ EHYEK 211_ AENGD 216_ LNWII 221_ PDRFI 226_ AFCGP 231_ HSRAR 236_ LESGY 241_ HQHSP 246_ ETYIQ 251_ YFKNH 256_ NVTTI 261_ IRLNK 266_ RMYDA 271_ KRFTD 276_ AGFDH 281_ HDLFF 286_ ADGST 291_ PTDAI 296_ VKEFL 301_ DICEN 306_ AEGAI 311_ AVHCK 316_ AGLGR 321_ TGTLI 326_ ACYIM 331_ KHYRM 336_ TAAET 341_ IAWVR 346_ ICRPG 351_ SVIGP 356_ QQQFL 361_ VMKQT 366_ NLWLE 371_ GDYFR 376_ QKLKG 381_ QENGQ 386_ HRAAF 391_ SKLLS 396_ GVDDI 401_ SINGV 406_ ENQDQ 411_ QEPEP 416_ YSDDD 421_ EINGV 426_ TQGDR 431_ LRALK 436_ SRRQS 441_ KTNAI 446_ PLTVI 451_ LQSSV 456_ QSCKT 461_ SEPNI 466_ SGSAG 471_ ITKRT 476_ TRSAS 481_ RKSSV 486_ KSLSI 491_SRTKT
1: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases