85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (2-lysophosphatidylcholine acylhydrolase) (EC 3.1.1.5) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9)
1_MQFFG 6_ RLVNT 11_ FSGVT 16_ NLFSN 21_ PFRVK 26_ EVAVA 31_ DYTSS 36_ DRVRE 41_ EGQLI 46_ LFQNT 51_ PNRTW 56_ DCVLV 61_ NPRNS 66_ QSGFR 71_ LFQLE 76_ LEADA 81_ LVNFH 86_ QYSSQ 91_ LLPFY 96_ ESSPQ 101_ VLHTE 106_ VLQHL 111_ TDLIR 116_ NHPSW 121_ SVAHL 126_ AVELG 131_ IRECF 136_ HHSRI 141_ ISCAN 146_ CAENE 151_ EGCTP 156_ LHLAC 161_ RKGDG 166_ EILVE 171_ LVQYC 176_ HTQMD 181_ VTDYK 186_ GETVF 191_ HYAVQ 196_ GDNSQ 201_ VLQLL 206_ GRNAV 211_ AGLNQ 216_ VNNQG 221_ LTPLH 226_ LACQL 231_ GKQEM 236_ VRVLL 241_ LCNAR 246_ CNIMG 251_ PNGYP 256_ IHSAM 261_ KFSQK 266_ GCAEM 271_ IISMD 276_ SSQIH 281_ SKDPR 286_ YGASP 291_ LHWAK 296_ NAEMA 301_ RMLLK 306_ RGCNV 311_ NSTSS 316_ AGNTA 321_ LHVAV 326_ MRNRF 331_ DCAIV 336_ LLTHG 341_ ANADA 346_ RGEHG 351_ NTPLH 356_ LAMSK 361_ DNVEM 366_ IKALI 371_ VFGAE 376_ VDTPN 381_ DFGET 386_ PTFLA 391_ SKIGR 396_ LVTRK 401_ AILTL 406_ LRTVG 411_ AEYCF 416_ PPIHG 421_ VPAEQ 426_ GSAAP 431_ HHPFS 436_ LERAQ 441_ PPPIS 446_ LNNLE 451_ LQDLM 456_ HISRA 461_ RKPAF 466_ ILGSM 471_ RDEKR 476_ THDHL 481_ LCLDG 486_ GGVKG 491_ LIIIQ 496_ LLIAI 501_ EKASG 506_ VATKD 511_ LFDWV 516_ AGTST 521_ GGILA 526_ LAILH 531_ SKSMA 536_ YMRGM 541_ YFRMK 546_ DEVFR 551_ GSRPY 556_ ESGPL 561_ EEFLK 566_ REFGE 571_ HTKMT 576_ DVRKP 581_ KVMLT 586_ GTLSD 591_ RQPAE 596_ LHLFR 601_ NYDAP 606_ ETVRE 611_ PRFNQ 616_ NVNLR 621_ PPAQP 626_ SDQLV 631_ WRAAR 636_ SSGAA 641_ PTYFR 646_ PNGRF 651_ LDGGL 656_ LANNP 661_ TLDAM 666_ TEIHE 671_ YNQDL 676_ IRKGQ 681_ ANKVK 686_ KLSIV 691_ VSLGT 696_ GRSPQ 701_ VPVTC 706_ VDVFR 711_ PSNPW 716_ ELAKT 721_ VFGAK 726_ ELGKM 731_ VVDCC 736_ TDPDG 741_ RAVDR 746_ ARAWC 751_ EMVGI 756_ QYFRL 761_ NPQLG 766_ TDIML 771_ DEVSD 776_ TVLVN 781_ ALWET 786_ EVYIY 791_ EHREE 796_ FQKLI 801_QLLLS
1: Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:10092647, PubMed:10336645, PubMed:20886109, PubMed:9417066). Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position (PubMed:10092647, PubMed:10336645, PubMed:20886109). Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity) (PubMed:20886109). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content (PubMed:23533611). Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species (By similarity). Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs) (By similarity). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle (PubMed:20886109). Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin (By similarity). Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis (PubMed:18208975). Targets membrane phospholipids to produce potent lipid signaling messengers. Generates lysophosphatidate (LPA, 1-acyl-glycerol-3-phosphate), which acts via G-protein receptors in various cell types (By similarity). Has phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid (By similarity). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion (By similarity)
2: Lacks the catalytic domain and may act as a negative regulator of the catalytically active isoforms
3: Lacks the catalytic domain and may act as a negative regulator of the catalytically active isoforms