Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9)
1_MAAER 6_ EPPPL 11_ GDGKP 16_ TDFED 21_ LEDGE 26_ DLFTS 31_ TVSTL 36_ ESSPS 41_ SPEPA 46_ SLPAE 51_ DISAN 56_ SNGPK 61_ PTEVV 66_ LDDDR 71_ EDLFA 76_ EATEE 81_ VSLDS 86_ PEREP 91_ ILSSE 96_ PSPAV 101_ TPVTP 106_ TTLIA 111_ PRIES 116_ KSMSA 121_ PVIFD 126_ RSREE 131_ IEEEA 136_ NGDIF 141_ DIEIG 146_ VSDPE 151_ KVGDG 156_ MNAYM 161_ AYRVT 166_ TKTSL 171_ SMFSK 176_ SEFSV 181_ KRRFS 186_ DFLGL 191_ HSKLA 196_ SKYLH 201_ VGYIV 206_ PPAPE 211_ KSIVG 216_ MTKVK 221_ VGKED 226_ SSSTE 231_ FVEKR 236_ RAALE 241_ RYLQR 246_ TVKHP 251_ TLLQD 256_ PDLRQ 261_ FLESS 266_ ELPRA 271_ VNTQA 276_ LSGAG 281_ ILRMV 286_ NKAAD 291_ AVNKM 296_ TIKMN 301_ ESDAW 306_ FEEKQ 311_ QQFEN 316_ LDQQL 321_ RKLHV 326_ SVEAL 331_ VCHRK 336_ ELSAN 341_ TAAFA 346_ KSAAM 351_ LGNSE 356_ DHTAL 361_ SRALS 366_ QLAEV 371_ EEKID 376_ QLHQE 381_ QAFAD 386_ FYMFS 391_ ELLSD 396_ YIRLI 401_ AAVKG 406_ VFDHR 411_ MKCWQ 416_ KWEDA 421_ QITLL 426_ KKREA 431_ EAKMM 436_ VANKP 441_ DKIQQ 446_ AKNEI 451_ REWEA 456_ KVQQG 461_ ERDFE 466_ QISKT 471_ IRKEV 476_ GRFEK 481_ ERVKD 486_ FKTVI 491_ IKYLE 496_ SLVQT 501_ QQQLI 506_ KYWEA 511_FLPEA
1: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901)