Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase)
1_MPNYK 6_ LTYFN 11_ MRGRA 16_ EIIRY 21_ IFAYL 26_ DIQYE 31_ DHRIE 36_ QADWP 41_ EIKST 46_ LPFGK 51_ IPILE 56_ VDGLT 61_ LHQSL 66_ AIARY 71_ LTKNT 76_ DLAGN 81_ TEMEQ 86_ CHVDA 91_ IVDTL 96_ DDFMS 101_ CFPWA 106_ EKKQD 111_ VKEQM 116_ FNELL 121_ TYNAP 126_ HLMQD 131_ LDTYL 136_ GGREW 141_ LIGNS 146_ VTWAD 151_ FYWEI 156_ CSTTL 161_ LVFKP 166_ DLLDN 171_ HPRLV 176_ TLRKK 181_ VQAIP 186_ AVANW 191_IKRRP
1: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide