Target of Myb protein 1
1_MDFLL 6_ GNPFS 11_ SPVGQ 16_ RIEKA 21_ TDGSL 26_ QSEDW 31_ ALNME 36_ ICDII 41_ NETEE 46_ GPKDA 51_ LRAVK 56_ KRIVG 61_ NKNFH 66_ EVMLA 71_ LTVLE 76_ TCVKN 81_ CGHRF 86_ HVLVA 91_ SQDFV 96_ ESVLV 101_ RTILP 106_ KNNPP 111_ TIVHD 116_ KVLNL 121_ IQSWA 126_ DAFRS 131_ SPDLT 136_ GVVTI 141_ YEDLR 146_ RKGLE 151_ FPMTD 156_ LDMLS 161_ PIHTP 166_ QRTVF 171_ NSETQ 176_ SGQDS 181_ VGTDS 186_ SQQED 191_ SGQHA 196_ APLPA 201_ PPILS 206_ GDTPI 211_ APTPE 216_ QIGKL 221_ RSELE 226_ MVSGN 231_ VRVMS 236_ EMLTE 241_ LVPTQ 246_ AEPAD 251_ LELLQ 256_ ELNRT 261_ CRAMQ 266_ QRVLE 271_ LIPQI 276_ ANEQL 281_ TEELL 286_ IVNDN 291_ LNNVF 296_ LRHER 301_ FERFR 306_ TGQTT 311_ KAPSE 316_ AEPAA 321_ DLIDM 326_ GPDPA 331_ ATGNL 336_ SSQLA 341_ GMNLG 346_ SSSVR 351_ AGLQS 356_ LEASG 361_ RLEDE 366_ FDMFA 371_ LTRGS 376_ SLADQ 381_ RKEVK 386_ YEAPQ 391_ ATDGL 396_ AGALD 401_ ARQQS 406_ TGAIP 411_ VTQAC 416_ LMEDI 421_ EQWLS 426_ TDVGN 431_ DAEEP 436_ KGVTS 441_ EEFDK 446_ FLEER 451_ AKAAD 456_ RLPNL 461_ SSPSA 466_ EGPPG 471_ PPSGP 476_ APRKK 481_ TQEKD 486_DDMLF
1: Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubMed:23023224, PubMed:25588840, PubMed:26320582, PubMed:31371777). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (PubMed:23023224). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (PubMed:23023224). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). Binds to polyubiquitinated proteins via its GAT domain (PubMed:14563850). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (PubMed:14563850, PubMed:15047686). Mediates clathrin recruitment to early endosomes by ZFYVE16 (PubMed:15657082). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (PubMed:26320582). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (PubMed:25588840). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (PubMed:25588840). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (PubMed:15047686, PubMed:26320582)