Coiled-coil domain-containing protein 22
1_MEEAD 6_ RILIH 11_ SLRQA 16_ GTAVP 21_ PDVQT 26_ LRAFT 31_ TELVV 36_ EAVVR 41_ CLRVI 46_ NPAVG 51_ SGLSP 56_ LLPLA 61_ MSARF 66_ RLAMS 71_ LAQAC 76_ MDLGY 81_ PLELG 86_ YQNFL 91_ YPSEP 96_ DLRDL 101_ LLFLA 106_ ERLPT 111_ DASED 116_ ADQPA 121_ GDSAI 126_ LLRAI 131_ GSQIR 136_ DQLAL 141_ PWVPP 146_ HLRTP 151_ KLQHL 156_ QGSAL 161_ QKPFH 166_ ASRLV 171_ VPELS 176_ SRGEP 181_ REFQA 186_ SPLLL 191_ PVPTQ 196_ VPQPV 201_ GRVAS 206_ LLEHH 211_ ALQLC 216_ QQTGR 221_ DRPGD 226_ EDWVH 231_ RTSRL 236_ PPQED 241_ TRAQR 246_ QRLQK 251_ QLTEH 256_ LRQSW 261_ GLLGA 266_ PIQAR 271_ DLGEL 276_ LQAWG 281_ AGAKT 286_ GAPKG 291_ SRFTH 296_ SEKFT 301_ FHLEP 306_ QAQAT 311_ QVSDV 316_ PATSR 321_ RPEQV 326_ TWAAQ 331_ EQELE 336_ SLREQ 341_ LEGVN 346_ RSIEE 351_ VEADM 356_ KTLGV 361_ SFVQA 366_ ESECR 371_ HSKLS 376_ TAERE 381_ QALRL 386_ KSRAV 391_ ELLPD 396_ GTANL 401_ AKLQL 406_ VVENS 411_ AQRVI 416_ HLAGQ 421_ WEKHR 426_ VPLLA 431_ EYRHL 436_ RKLQD 441_ CRELE 446_ SSRRL 451_ AEIQE 456_ LHQSV 461_ RAAAE 466_ EARRK 471_ EEVYK 476_ QLMSE 481_ LETLP 486_ RDVSR 491_ LAYTQ 496_ RILEI 501_ VGNIR 506_ KQKEE 511_ ITKIL 516_ SDTKE 521_ LQKEI 526_ NSLSG 531_ KLDRT 536_ FAVTD 541_ ELVFK 546_ DAKKD 551_ DAVRK 556_ AYKYL 561_ AALHE 566_ NCSQL 571_ IQTIE 576_ DTGTI 581_ MREVR 586_ DLEEQ 591_ IETEL 596_ GKKTL 601_ SNLEK 606_ IREDY 611_ RALRQ 616_ ENAGL 621_LGRVR
1: Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the Commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels (PubMed:37172566, PubMed:38459129). Involved in regulation of NF-kappa-B signaling (PubMed:23563313). Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex (PubMed:23563313). May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:25355947, PubMed:28892079). Plays a role in copper ion homeostasis (PubMed:25355947). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947)
2: (Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface