Polyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1)
1_MPLPV 6_ ALQTR 11_ LAKRG 16_ ILKHL 21_ EPEPE 26_ EEIIA 31_ EDYDD 36_ DPVDY 41_ EATRL 46_ EGLPP 51_ SWYKV 56_ FDPSC 61_ GLPYY 66_ WNADT 71_ DLVSW 76_ LSPHD 81_ PNSVV 86_ TKSAK 91_ KLRSS 96_ NADAE 101_ EKLDR 106_ SHDKS 111_ DRGHD 116_ KSDRS 121_ HEKLD 126_ RGHDK 131_ SDRGH 136_ DKSDR 141_ DRERG 146_ YDKVD 151_ RERER 156_ DRERD 161_ RDRGY 166_ DKADR 171_ EEGKE 176_ RRHHR 181_ REELA 186_ PYPKS 191_ KKAVS 196_ RKDEE 201_ LDPMD 206_ PSSYS 211_ DAPRG 216_ TWSTG 221_ LPKRN 226_ EAKTG 231_ ADTTA 236_ AGPLF 241_ QQRPY 246_ PSPGA 251_ VLRAN 256_AEASR
1: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437)