H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)
1_MADAE 6_ VIILP 11_ KKHKK 16_ KKERK 21_ SLPEE 26_ DVAEI 31_ QHAEE 36_ FLIKP 41_ ESKVA 46_ KLDTS 51_ QWPLL 56_ LKNFD 61_ KLNVR 66_ TTHYT 71_ PLACG 76_ SNPLK 81_ REIGD 86_ YIRTG 91_ FINLD 96_ KPSNP 101_ SSHEV 106_ VAWIR 111_ RILRV 116_ EKTGH 121_ SGTLD 126_ PKVTG 131_ CLIVC 136_ IERAT 141_ RLVKS 146_ QQSAG 151_ KEYVG 156_ IVRLH 161_ NAIEG 166_ GTQLS 171_ RALET 176_ LTGAL 181_ FQRPP 186_ LIAAV 191_ KRQLR 196_ VRTIY 201_ ESKMI 206_ EYDPE 211_ RRLGI 216_ FWVSC 221_ EAGTY 226_ IRTLC 231_ VHLGL 236_ LLGVG 241_ GQMQE 246_ LRRVR 251_ SGVMS 256_ EKDHM 261_ VTMHD 266_ VLDAQ 271_ WLYDN 276_ HKDES 281_ YLRRV 286_ VYPLE 291_ KLLTS 296_ HKRLV 301_ MKDSA 306_ VNAIC 311_ YGAKI 316_ MLPGV 321_ LRYED 326_ GIEVN 331_ QEIVV 336_ ITTKG 341_ EAICM 346_ AIALM 351_ TTAVI 356_ STCDH 361_ GIVAK 366_ IKRVI 371_ MERDT 376_ YPRKW 381_ GLGPK 386_ ASQKK 391_ LMIKQ 396_ GLLDK 401_ HGKPT 406_ DSTPA 411_ TWKQE 416_ YVDYS 421_ ESAKK 426_ EVVAE 431_ VVKAP 436_ QVVAE 441_ AAKTA 446_ KRKRE 451_ SESES 456_ DETPP 461_ AAPQL 466_ IKKEK 471_ KKSKK 476_ DKKAK 481_ AGLES 486_ GAEPG 491_ DGDSD 496_ TTKKK 501_ KKKKK 506_AKEVE
1: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534)
2: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression