Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2)
1_MGKKQ 6_ KNKSE 11_ DSTKD 16_ DIDLD 21_ ALAAE 26_ IEGAG 31_ AAKEQ 36_ EPQKS 41_ KGKKK 46_ KEKKK 51_ QDFDE 56_ DDILK 61_ ELEEL 66_ SLEAQ 71_ GIKAD 76_ RETVA 81_ VKPTE 86_ NNEEE 91_ FTSKD 96_ KKKKG 101_ QKGKK 106_ QSFDD 111_ NDSEE 116_ LEDKD 121_ SKSKK 126_ TAKPK 131_ VEMYS 136_ GSDDD 141_ DDFNK 146_ LPKKA 151_ KGKAQ 156_ KSNKK 161_ WDGSE 166_ EDEDN 171_ SKKIK 176_ ERSRI 181_ NSSGE 186_ SGDES 191_ DEFLQ 196_ SRKGQ 201_ KKNQK 206_ NKPGP 211_ NIESG 216_ NEDDD 221_ ASFKI 226_ KTVAQ 231_ KKAEK 236_ KERER 241_ KKRDE 246_ EKAKL 251_ RKLKE 256_ KEELE 261_ TGKKD 266_ QSKQK 271_ ESQRK 276_ FEEET 281_ VKSKV 286_ TVDTG 291_ VIPAS 296_ EEKAE 301_ TPTAA 306_ EDDNE 311_ GDKKK 316_ KDKKK 321_ KKGEK 326_ EEKEK 331_ EKKKG 336_ PSKAT 341_ VKAMQ 346_ EALAK 351_ LKEEE 356_ ERQKR 361_ EEEER 366_ IKRLE 371_ ELEAK 376_ RKEEE 381_ RLEQE 386_ KRERK 391_ KQKEK 396_ ERKER 401_ LKKEG 406_ KLLTK 411_ SQREA 416_ RARAE 421_ ATLKL 426_ LQAQG 431_ VEVPS 436_ KDSLP 441_ KKRPI 446_ YEDKK 451_ RKKIP 456_ QQLES 461_ KEVSE 466_ SMELC 471_ AAVEV 476_ MEQGV 481_ PEKEE 486_ TPPPV 491_ EPEEE 496_ EDTED 501_ AGLDD 506_ WEAMA 511_ SDEET 516_ EKVEG 521_ NKVHI 526_ EVKEN 531_ PEEEE 536_ EEEEE 541_ EEEDE 546_ ESEEE 551_ EEEEG 556_ ESEGS 561_ EGDEE 566_ DEKVS 571_ DEKDS 576_ GKTLD 581_ KKPSK 586_ EMSSD 591_ SEYDS 596_ DDDRT 601_ KEERA 606_ YDKAK 611_ RRIEK 616_ RRLEH 621_ SKNVN 626_ TEKLR 631_ APIIC 636_ VLGHV 641_ DTGKT 646_ KILDK 651_ LRHTH 656_ VQDGE 661_ AGGIT 666_ QQIGA 671_ TNVPL 676_ EAINE 681_ QTKMI 686_ KNFDR 691_ ENVRI 696_ PGMLI 701_ IDTPG 706_ HESFS 711_ NLRNR 716_ GSSLC 721_ DIAIL 726_ VVDIM 731_ HGLEP 736_ QTIES 741_ INLLK 746_ SKKCP 751_ FIVAL 756_ NKIDR 761_ LYDWK 766_ KSPDS 771_ DVAAT 776_ LKKQK 781_ KNTKD 786_ EFEER 791_ AKAII 796_ VEFAQ 801_ QGLNA 806_ ALFYE 811_ NKDPR 816_ TFVSL 821_ VPTSA 826_ HTGDG 831_ MGSLI 836_ YLLVE 841_ LTQTM 846_ LSKRL 851_ AHCEE 856_ LRAQV 861_ MEVKA 866_ LPGMG 871_ TTIDV 876_ ILING 881_ RLKEG 886_ DTIIV 891_ PGVEG 896_ PIVTQ 901_ IRGLL 906_ LPPPM 911_ KELRV 916_ KNQYE 921_ KHKEV 926_ EAAQG 931_ VKILG 936_ KDLEK 941_ TLAGL 946_ PLLVA 951_ YKEDE 956_ IPVLK 961_ DELIH 966_ ELKQT 971_ LNAIK 976_ LEEKG 981_ VYVQA 986_ STLGS 991_ LEALL 996_ EFLKT 1001_ SEVPY 1006_ AGINI 1011_ GPVHK 1016_ KDVMK 1021_ ASVML 1026_ EHDPQ 1031_ YAVIL 1036_ AFDVR 1041_ IERDA 1046_ QEMAD 1051_ SLGVR 1056_ IFSAE 1061_ IIYHL 1066_ FDAFT 1071_ KYRQD 1076_ YKKQK 1081_ QEEFK 1086_ HIAVF 1091_ PCKIK 1096_ ILPQY 1101_ IFNSR 1106_ DPIVM 1111_ GVTVE 1116_ AGQVK 1121_ QGTPM 1126_ CVPSK 1131_ NFVDI 1136_ GIVTS 1141_ IEINH 1146_ KQVDV 1151_ AKKGQ 1156_ EVCVK 1161_ IEPIP 1166_ GESPK 1171_ MFGRH 1176_ FEATD 1181_ ILVSK 1186_ ISRQS 1191_ IDALK 1196_ DWFRD 1201_ EMQKS 1206_ DWQLI 1211_VELKK
1: Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855)