E3 ubiquitin-protein ligase TRIM13 (EC 2.3.2.27) (B-cell chronic lymphocytic leukemia tumor suppressor Leu5) (Leukemia-associated protein 5) (Putative tumor suppressor RFP2) (RING finger protein 77) (RING-type E3 ubiquitin transferase TRIM13) (Ret finger protein 2) (Tripartite motif-containing protein 13)
1_MELLE 6_ EDLTC 11_ PICCS 16_ LFDDP 21_ RVLPC 26_ SHNFC 31_ KKCLE 36_ GILEG 41_ SVRNS 46_ LWRPA 51_ PFKCP 56_ TCRKE 61_ TSATG 66_ INSLQ 71_ VNYSL 76_ KGIVE 81_ KYNKI 86_ KISPK 91_ MPVCK 96_ GHLGQ 101_ PLNIF 106_ CLTDM 111_ QLICG 116_ ICATR 121_ GEHTK 126_ HVFCS 131_ IEDAY 136_ AQERD 141_ AFESL 146_ FQSFE 151_ TWRRG 156_ DALSR 161_ LDTLE 166_ TSKRK 171_ SLQLL 176_ TKDSD 181_ KVKEF 186_ FEKLQ 191_ HTLDQ 196_ KKNEI 201_ LSDFE 206_ TMKLA 211_ VMQAY 216_ DPEIN 221_ KLNTI 226_ LQEQR 231_ MAFNI 236_ AEAFK 241_ DVSEP 246_ IVFLQ 251_ QMQEF 256_ REKIK 261_ VIKET 266_ PLPPS 271_ NLPAS 276_ PLMKN 281_ FDTSQ 286_ WEDIK 291_ LVDVD 296_ KLSLP 301_ QDTGT 306_ FISKI 311_ PWSFY 316_ KLFLL 321_ ILLLG 326_ LVIVF 331_ GPTMF 336_ LEWSL 341_ FDDLA 346_ TWKGC 351_ LSNFS 356_ SYLTK 361_ TADFI 366_ EQSVF 371_ YWEQV 376_ TDGFF 381_ IFNER 386_ FKNFT 391_ LVVLN 396_ NVAEF 401_VCKYK
1: Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor (PubMed:22178386). Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809). Participates as well in T-cell receptor-mediated NF-kappa-B activation (PubMed:25088585). In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B (PubMed:25152375)