Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1)
1_MAESD 6_ WDTVT 11_ VLRKK 16_ GPTAA 21_ QAKSK 26_ QAILA 31_ AQRRG 36_ EDVET 41_ SKKWA 46_ AGQNK 51_ QHSIT 56_ KNTAK 61_ LDRET 66_ EELHH 71_ DRVTL 76_ EVGKV 81_ IQQGR 86_ QSKGL 91_ TQKDL 96_ ATKIN 101_ EKPQV 106_ IADYE 111_ SGRAI 116_ PNNQV 121_ LGKIE 126_ RAIGL 131_ KLRGK 136_ DIGKP 141_IEKGP
1: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism