SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
1_MDAVA 6_ VYHGK 11_ ISRET 16_ GEKLL 21_ LATGL 26_ DGSYL 31_ LRDSE 36_ SVPGV 41_ YCLCV 46_ LYHGY 51_ IYTYR 56_ VSQTE 61_ TGSWS 66_ AETAP 71_ GVHKR 76_ YFRKI 81_ KNLIS 86_ AFQKP 91_ DQGIV 96_ IPLQY 101_ PVEKK 106_ SSARS 111_ TQGTT 116_ GIRED 121_PDVCL
1: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3