G-protein coupled receptor 37-like 1 (Endothelin B receptor-like protein 2) (ETBR-LP-2)
1_MRWLW 6_ PLAVS 11_ LAVIL 16_ AVGLS 21_ RVSGG 26_ APLHL 31_ GRHRA 36_ ETQEQ 41_ QSRSK 46_ RGTED 51_ EEAKG 56_ VQQYV 61_ PEEWA 66_ EYPRP 71_ IHPAG 76_ LQPTK 81_ PLVAT 86_ SPNPG 91_ KDGGT 96_ PDSGQ 101_ ELRGN 106_ LTGAP 111_ GQRLQ 116_ IQNPL 121_ YPVTE 126_ SSYSA 131_ YAIML 136_ LALVV 141_ FAVGI 146_ VGNLS 151_ VMCIV 156_ WHSYY 161_ LKSAW 166_ NSILA 171_ SLALW 176_ DFLVL 181_ FFCLP 186_ IVIFN 191_ EITKQ 196_ RLLGD 201_ VSCRA 206_ VPFME 211_ VSSLG 216_ VTTFS 221_ LCALG 226_ IDRFH 231_ VATST 236_ LPKVR 241_ PIERC 246_ QSILA 251_ KLAVI 256_ WVGSM 261_ TLAVP 266_ ELLLW 271_ QLAQE 276_ PAPTM 281_ GTLDS 286_ CIMKP 291_ SASLP 296_ ESLYS 301_ LVMTY 306_ QNARM 311_ WWYFG 316_ CYFCL 321_ PILFT 326_ VTCQL 331_ VTWRV 336_ RGPPG 341_ RKSEC 346_ RASKH 351_ EQCES 356_ QLNST 361_ VVGLT 366_ VVYAF 371_ CTLPE 376_ NVCNI 381_ VVAYL 386_ STELT 391_ RQTLD 396_ LLGLI 401_ NQFST 406_ FFKGA 411_ ITPVL 416_ LLCIC 421_ RPLGQ 426_ AFLDC 431_ CCCCC 436_ CEECG 441_ GASEA 446_ SAANG 451_ SDNKL 456_ KTEVS 461_ SSIYF 466_ HKPRE 471_ SPPLL 476_PLGTP
1: G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity)