Bromodomain-containing protein 4 (Protein HUNK1)
1_MSAES 6_ GPGTR 11_ LRNLP 16_ VMGDG 21_ LETSQ 26_ MSTTQ 31_ AQAQP 36_ QPANA 41_ ASTNP 46_ PPPET 51_ SNPNK 56_ PKRQT 61_ NQLQY 66_ LLRVV 71_ LKTLW 76_ KHQFA 81_ WPFQQ 86_ PVDAV 91_ KLNLP 96_ DYYKI 101_ IKTPM 106_ DMGTI 111_ KKRLE 116_ NNYYW 121_ NAQEC 126_ IQDFN 131_ TMFTN 136_ CYIYN 141_ KPGDD 146_ IVLMA 151_ EALEK 156_ LFLQK 161_ INELP 166_ TEETE 171_ IMIVQ 176_ AKGRG 181_ RGRKE 186_ TGTAK 191_ PGVST 196_ VPNTT 201_ QASTP 206_ PQTQT 211_ PQPNP 216_ PPVQA 221_ TPHPF 226_ PAVTP 231_ DLIVQ 236_ TPVMT 241_ VVPPQ 246_ PLQTP 251_ PPVPP 256_ QPQPP 261_ PAPAP 266_ QPVQS 271_ HPPII 276_ AATPQ 281_ PVKTK 286_ KGVKR 291_ KADTT 296_ TPTTI 301_ DPIHE 306_ PPSLP 311_ PEPKT 316_ TKLGQ 321_ RRESS 326_ RPVKP 331_ PKKDV 336_ PDSQQ 341_ HPAPE 346_ KSSKV 351_ SEQLK 356_ CCSGI 361_ LKEMF 366_ AKKHA 371_ AYAWP 376_ FYKPV 381_ DVEAL 386_ GLHDY 391_ CDIIK 396_ HPMDM 401_ STIKS 406_ KLEAR 411_ EYRDA 416_ QEFGA 421_ DVRLM 426_ FSNCY 431_ KYNPP 436_ DHEVV 441_ AMARK 446_ LQDVF 451_ EMRFA 456_ KMPDE 461_ PEEPV 466_ VAVSS 471_ PAVPP 476_ PTKVV 481_ APPSS 486_ SDSSS 491_ DSSSD 496_ SDSST 501_ DDSEE 506_ ERAQR 511_ LAELQ 516_ EQLKA 521_ VHEQL 526_ AALSQ 531_ PQQNK 536_ PKKKE 541_ KDKKE 546_ KKKEK 551_ HKRKE 556_ EVEEN 561_ KKSKA 566_ KEPPP 571_ KKTKK 576_ NNSSN 581_ SNVSK 586_ KEPAP 591_ MKSKP 596_ PPTYE 601_ SEEED 606_ KCKPM 611_ SYEEK 616_ RQLSL 621_ DINKL 626_ PGEKL 631_ GRVVH 636_ IIQSR 641_ EPSLK 646_ NSNPD 651_ EIEID 656_ FETLK 661_ PSTLR 666_ ELERY 671_ VTSCL 676_ RKKRK 681_ PQAEK 686_ VDVIA 691_ GSSKM 696_ KGFSS 701_ SESES 706_ SSESS 711_ SSDSE 716_ DSETE 721_ MAPKS 726_ KKKGH 731_ PGREQ 736_ KKHHH 741_ HHHQQ 746_ MQQAP 751_ APVPQ 756_ QPPPP 761_ PQQPP 766_ PPPPP 771_ QQQQQ 776_ PPPPP 781_ PPPSM 786_ PQQAA 791_ PAMKS 796_ SPPPF 801_ IATQV 806_ PVLEP 811_ QLPGS 816_ VFDPI 821_ GHFTQ 826_ PILHL 831_ PQPEL 836_ PPHLP 841_ QPPEH 846_ STPPH 851_ LNQHA 856_ VVSPP 861_ ALHNA 866_ LPQQP 871_ SRPSN 876_ RAAAL 881_ PPKPA 886_ RPPAV 891_ SPALT 896_ QTPLL 901_ PQPPM 906_ AQPPQ 911_ VLLED 916_ EEPPA 921_ PPLTS 926_ MQMQL 931_ YLQQL 936_ QKVQP 941_ PTPLL 946_ PSVKV 951_ QSQPP 956_ PPLPP 961_ PPHPS 966_ VQQQL 971_ QQQPP 976_ PPPPP 981_ QPQPP 986_ PQQQH 991_ QPPPR 996_ PVHLQ 1001_ PMQFS 1006_ THIQQ 1011_ PPPPQ 1016_ GQQPP 1021_ HPPPG 1026_ QQPPP 1031_ PQPAK 1036_ PQQVI 1041_ QHHHS 1046_ PRHHK 1051_ SDPYS 1056_ TGHLR 1061_ EAPSP 1066_ LMIHS 1071_ PQMSQ 1076_ FQSLT 1081_ HQSPP 1086_ QQNVQ 1091_ PKKQE 1096_ LRAAS 1101_ VVQPQ 1106_ PLVVV 1111_ KEEKI 1116_ HSPII 1121_ RSEPF 1126_ SPSLR 1131_ PEPPK 1136_ HPESI 1141_ KAPVH 1146_ LPQRP 1151_ EMKPV 1156_ DVGRP 1161_ VIRPP 1166_ EQNAP 1171_ PPGAP 1176_ DKDKQ 1181_ KQEPK 1186_ TPVAP 1191_ KKDLK 1196_ IKNMG 1201_ SWASL 1206_ VQKHP 1211_ TTPSS 1216_ TAKSS 1221_ SDSFE 1226_ QFRRA 1231_ AREKE 1236_ EREKA 1241_ LKAQA 1246_ EHAEK 1251_ EKERL 1256_ RQERM 1261_ RSRED 1266_ EDALE 1271_ QARRA 1276_ HEEAR 1281_ RRQEQ 1286_ QQQQR 1291_ QEQQQ 1296_ QQQQQ 1301_ AAAVA 1306_ AAATP 1311_ QAQSS 1316_ QPQSM 1321_ LDQQR 1326_ ELARK 1331_ REQER 1336_ RRREA 1341_ MAATI 1346_ DMNFQ 1351_ SDLLS 1356_IFEEN
1: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504)
2: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation